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- Solarbio|ActivAb
- 北京
- CLP0077
- 2025年07月29日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃，2 years.(Avoid freeze/thaw cycles)
- 保质期：
Store at -20℃，2 years.(Avoid freeze/thaw cycles)
- 英文名：
MART-1(26-35))(human)
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
10mg/5mg/1mg
| 规格： | 10mg | 产品价格： | ￥2170.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥1550.0 |
| 规格： | 1mg | 产品价格： | ￥620.0 |
| 基本信息 | |
| 产品类型 | 多肽 |
| CAS | No.197794-83-5 |
| 单字母序列 | TFLLR-NH2 |
| 三字母序列 | Thr-Phe-Leu-Leu-Arg-NH2 |
| 别名 | 血酶受体;(Thr1)-PAR-1 (1-5) amide (human);TFLLR-NH2 Protease-Activated Receptor 1 (PAR1) Agonist |
| 分子式 | C31H53N9O6 |
| 分子量 | 647.82 |
| 纯度 | ≥95% |
| 外观(性状) | 冻干粉;Lyophilized powder |
| 溶解性 | H2O：100 mg/mL; DMSO：100 mg/mL; *超声助溶; |
| 盐体系 | TFA盐;Trifluoroacetate salt |
| 来源 | 合成;Synthetic |
| 储存条件 | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| 类别/标签 | 蛋白激酶相关肽(Protein Kinase Related Peptides) |
| 规格 | TFLLR-NH2是选择性的PAR1激动剂，EC50值为1.9 μM。TFLLR-NH2 is a selective PAR1 agonist with an EC50 of 1.9 μM. |
| In Vitro | PAR1 agonists stimulate concentration-dependent increases in [Ca2+]i and in the proportions of neurones. The maximal increase in [Ca2+]i above basal is detected in response to 10 μm TF-NH2 (peak 196.5±20.4 nM, n=25) when 50–80% of identified neurones responded. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E-cadherin expression and downregulate the vimentin expression. In the in vitro platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant. |
| In Vivo | Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1 h and completely by 5 h. In wild-type but not PAR1 / mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp-NH2-induced relaxation is blocked by apamin at 0.1 μM. |
| 单位 | 瓶 |
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文献和实验【整理】2006年01月01日 - 2006年02月30日两月来的无应答帖 希望各位战友积极应助
【整理】2006年01月01日 - 2006年02月30日两月来的无应答帖 希望各位战友积极应助 辛苦了！谢谢！by mybbff (求助)关于real time PCR 操作软件opticon 2 http://www.dxy.cn/bbs/post/view?bid=64&id=5328144&sty=1&tpg=33&age=0 [求购]红细胞裂解液 http://www.dxy.cn/bbs/post/view?bid=64&id=5580426&sty=1&tpg
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-like liver organoids. Journal of hepatology, 2019, 71.5: 970-985. 【3】Nie, Y. Z. et al.(2018). Recapitulation of hepatitis B virus–host interactions in liver organoids from human induced pluripotent stem cells. EBioMedicine, 35, 114-123. 【4】Ouchi, R. et al
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