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- Solarbio
- P00927
- 北京
- 2025年07月25日
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- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥15360.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥10752.0 |
| 规格： | 50ug | 产品价格： | ￥2600.0 |
| 规格： | 10ug | 产品价格： | ￥936.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | antiangiogenic agent;COL18A1;collagen alpha-1(XVIII)chain;collagen;type XVIII;Endostatin |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Endostatin，an endogenous non-glycosylated inhibitor of endothelial cell proliferation and angiogenesis.It is produced and/or trimmed by metalloproteinases such as MMP-2 and MMP-9，and cathepsins S，B and L.The N-terminal ~27 aa of Endostatin appear to contain the majority of its activity.This region contains zinc binding sites that are thought to be critical for its anti-endothelial and anti-tumor effects，as well as multiple cleavage sites that，when used，can modify its activity.Mouse Endostatin shares 96% aa sequence identity with rat and 85-87% with human，bovine and equine Endostatin.It is predominantly expressed in liver，kidney，lung，skeletal muscle and testis.Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis.It is also thought to down-regulate angiogenesis by blocking VEGF-induced endothelial cell migration.Endostatin may also be involved with down-regulation of angiogenesis after establishment of placental circulation in the pregnant uterus. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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Performing Bronchoalveolar Lavage in the Mouse
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