P00919 Recombinant Mouse IL-4
R alpha/CD124/IL-4RA/IL-4R/Interleukin-4 Receptor Subunit Alpha/prot 细胞因子/蛋白- ￥936 - 17280
- Solarbio
- P00919
- 北京
- 2025年07月25日
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- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥17280.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥12096.0 |
| 规格： | 50ug | 产品价格： | ￥2600.0 |
| 规格： | 10ug | 产品价格： | ￥936.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Interleukin-4 receptor subunit alpha;IL-4R-alpha;CD124;IL4-BP;Soluble IL-4R-alpha;IL-4RA |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Interleukin-4 receptor subunit alpha(IL-4RA)，alos known as Soluble IL-4 receptor subunit alpha，belongs to the type I cytokine receptor family and type 4 subfamily.It expressed in both Th1 and Th2 cells.It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway.The IL4 response is involved in promoting Th2 differentiation.The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation.In certain cell types，IL-4RA can signal through activation of insulin receptor substrates，IRS1/IRS2.The functional IL4 receptor is formed by initial binding of IL4 to IL4R.Subsequently it recruits to the complex of the common gamma chain.In immune cells，IL-4RA creates a type I receptor.In non-immune cells，it forms a type II receptor with of IL13RA1.IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases，PTPN6/SHIP1，PTPN11/SHIP2 and INPP5D/SHIP. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验大家也可以运用 R 语言绘制这样的图形，一个超长的函数也可以简单的拆分成几个小命令：> p +geom_bar(stat = "identity",width = 0.6,alpha=.9) #柱状图基本设置+ guides(fill=guide_legend(reverse = T)) #图例设置+coord_flip() #反转坐标+ theme_bw() + theme(panel.grid.major = element_blank(),panel.grid.minor = element
信号；⑤进一步活化的T细胞更多表达CD401。和分泌细胞因子，其中较重要的如IL-4。与B细胞表面的IL-4R结合．促使B细胞进一步活化并开始增殖分化。参与B激活的其他分子还包括CD30与CD30L(CDl53)、41BB与41BBL、B7-RP与ICOS等，细胞因子IL-5和II．-6则在B细胞激活的后期发挥作用。 图10-7 T细胞与B细胞之间的相互作用图中圆圈内由文字代表第二信号；注意最终生成的抗体是针对抗原B表位(绿色)而非T表位(红色)。2.T、B细胞相互作用的特异性 需要指出
Intracellular Cytokine Staining Protocol
-gamma, TNF-alpha, IL-2, and IL-4, a combination of PMA (a PKC activator) and Ionomycin (a calcium ionophore) or anti-CD3 antibodies are used. To induce IL-6, IL-10 or TNF-alpha production by monocytes, stimulation of PBMC's with LPS is used.Note: Optimal
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