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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥16800.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥11760.0 |
| 规格： | 50ug | 产品价格： | ￥2288.0 |
| 规格： | 10ug | 产品价格： | ￥728.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | MHC Class I Polypeptide-Related Sequence A;MIC-A;MICA;PERB11.1 |
| 中文名称 | Recombinant Human MICA/MHC-I related sequence A |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | MHC Class I Polypeptide-Related Sequence A (MICA) is a transmembrane glycoprotein that functions as a ligand for human NKG2D.Unlike classical MHC class I molecules，MICA does not form a heterodimer with beta-2-microglobulin.MICA shares 85% amino acid identity with a closely related protein，MICB.MICA acts as a stress-induced self-antigen that is recognized by NK cells，NKT cells，and most of the subtypes of T cells.As a Ligand for the KLRK1/NKG2D receptor，MICA binds to KLRK1 leads to cell lysis.MICA functions as an antigen for gamma delta T cells and is frequently expressed in epithelial tumors.MICA antigens are able to elicit the synthesis of alloantibodies in transplant recipients.Studies have shown that anti-MICA antibodies are associated with acute renal allograft rejection and failure.MICA recognition is involved in tumor surveillance，viral infections，and autoimmune diseases. |
| 来源 | Human Cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验Using BLAT to Find Sequence Similarity in Closely Related Genomes
to 38280703, corresponding to the first match. This region is depicted by a red rectangle in the p arm of the chromosome X ideogram. The box below the ideogram displays two tracks. The top track, labeled “Your Sequence from BLAT Search”, shows the alignment
Hydrophobicity Profiles for Protein Sequence Analysis
. Biol. 97:237‐256. Finzel, B.C., Clancy, L.L., Holland, D.R., Muchmore, S.W., Watenpaugh, K.D., and Einspahr, H.M. 1989. Crystal structure of recombinant human interleukin‐1β
Using Bioinformatics Tools for the Sequence Analysis of Immunoglobulins and T Cell Receptors
., and Lefranc, M.‐P. 2005a. IMGT/GENE‐DB: A comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucl. Acids Res. 33:D256‐D261. Giudicelli, V., Chaume
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