P00235 Recombinant Human Cyto

Recombinant Human Cytotoxic T-lymphocyte Protein 4 is produced by our Mammalian expression system and the target gene encoding Lys36-Asp161 is expressed with a Flag tag at the C-terminus.

基本信息
基因名
别名	Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;CTLA-4;CD152;CTLA4
外观(性状)	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度	≥95% as determined by reducing SDS-PAGE.
储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件	The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below.
背景说明	Cytotoxic Tlymphocyte 4(CTLA-4，CD152)，is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.Human or mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence，a 126 aa extracellular domain (ECD) with one Ig-like V-type domain，a 21 aa transmembrane (TM) sequence，and a 41 aa cytoplasmic sequence.It is widely expressed with highest levels in lymphoid tissues.CD28 and CTLA-4，together with their ligands，B7-1 and B7-2，constitute one of the dominant costimulatory pathways that regulate T and B cell responses.CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily.CTLA4 transmits an inhibitory signal to T cells，whereas CD28 transmits a stimulatory signal.Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions.Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
来源	Human cells
溶剂	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素	Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.
单位	支