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P00410 Recombinant Human SMAD4

/SMAD family member 4 细胞因子/蛋白
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  • ¥468 - 21120
  • Solarbio已认证
  • P00410
  • 北京
  • 2025年07月25日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 库存

      现询

    • 供应商

      北京索莱宝科技有限公司

    • 规格

      1mg/500ug/50ug/10ug

    规格:1mg产品价格:¥21120.0
    规格:500ug产品价格:¥14784.0
    规格:50ug产品价格:¥2964.0
    规格:10ug产品价格:¥468.0
    基本信息
    基因名
    别名Mothers Against Decapentaplegic Homolog 4;MAD Homolog 4;Mothers Against DPP Homolog 4;Deletion Target in Pancreatic Carcinoma 4;SMAD Family Member 4;SMAD 4;Smad4;hSMAD4;SMAD4;DPC4;MADH4
    中文名称Recombinant Human SMAD4/SMAD family member 4
    外观(性状)Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, pH8.0.
    纯度Greater than85% as determined by reducing SDS-PAGE.
    储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
    运输条件The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below.
    背景说明SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family.SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain.It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling.SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription.SMAD4 may act as a tumor suppressor.It positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.Mutations or deletions in SMAD4 have been shown to result in pancreatic cancer,juvenile polyposis syndrome,and hereditary hemorrhagic telangiectasia syndrome.
    来源E.coli
    溶剂Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    内毒素Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.
    单位

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