P00149 Recombinant Human PDCD

Recombinant Human Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu25-Gln167 is expressed with a 6His tag at the C-terminus.

基本信息
基因名
别名	Programmed cell death protein 1;hPD-1;PDCD1;CD279
外观(性状)	Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.
纯度	≥95% as determined by reducing SDS-PAGE.
储存条件	Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.
运输条件	The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below.
背景说明	Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain.PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators.PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1，IL-4，IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway.In addition，coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer.PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance，and thus contributes to the prevention of autoimmune diseases.As a cell surface molecule，PDCD1 regulates the adaptive immune response.Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation，cytokine production，and cytolytic function.
来源	Human cells
溶剂	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素	Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.
单位	支