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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-5~-20℃,避光储存
- 保质期:
12个月
- 英文名:
A83-01 Solution (50 mM)
- 库存:
99
- 供应商:
武汉普诺赛生命科技有限公司
- CAS号:
无
- 规格:
0.1mL
产品描述:
A83-01是一个强有力的TGF-βⅠ型受体激酶的抑制剂如:ALK5(IC50:12 nm)、ALK4(IC50:45 nm)、ALK 7(IC50:7.5 nm),A83-01对ALK5的抑制作用很强,可以抑制Smad2/3的磷酸化和TGF-β诱导的生长。A83-01对骨形态发生蛋白I型受体、p38丝裂原活化蛋白激酶或细胞外调节激酶的作用很小或没有作用。同时,A83-01可抑制TGF-β诱导的上皮-间充质转移,表明A83-01可能有助于抑制晚期癌症的进程。
优势特点:
A83-01在类器官培养过程中一般用于肝脏、前列腺以及乳腺类器官的培养,常被用于抑制iPSCs的分化,维持体外细胞的自我更新。
产品储存方法:
将A83-01溶液(50 mM) -5~-20℃,避光储存,有效期为12个月
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