- ￥1190 - 3490
- Solarbio
- 北京
- IA7470
- 2025年10月10日
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- 详细信息
- 技术资料
- 保存条件：
Powder:-20℃，1 year;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，1 year;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Aviptadil
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
40077-57-4
- 规格：
10mg/5mg/1mg
| 规格： | 10mg | 产品价格： | ￥3490.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥2490.0 |
| 规格： | 1mg | 产品价格： | ￥1190.0 |
| 基本信息 | |
| CAS | No.40077-57-4 |
| 中文名称 | 阿肽地尔 |
| 英文名称 | Aviptadil |
| 别名 | Vasoactive Intestinal Peptide (human);rat;mouse;rabbit;canine;porcine |
| 分子式 | C147H238N44O42S |
| 分子量 | 3325.8 |
| 溶解性 | Soluble in DMSO ≥3mg/mL(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，1 year;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00167535 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | Aviptadil是一种血管活性肠多肽类似物，具有强的血管舒张 (vasodilatory) 活性。Aviptadil 可用于肺纤维化、肺动脉高压 (PAH)、SARS-CoV-2 引起呼吸衰竭等的研究。 |
| 生物活性 | Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation， platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis， pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure， et al[1][2][3][4] |
| In Vitro | Within 3 weeks of a single injection of monocrotaline (MCT， s.c.) in Sprague Dawley rats， PAH developed， manifested by pulmonary vascular remodeling， lung inflammation， RV hypertrophy， and death within the next 2 weeks. MCT - injected Animals were either untreated， treated with bosentan (p.o.) alone， with VIP (i.p.) alone， or with both together. We selected this particular combination upon finding that VIP down - regulates Endothelin Receptor expression which is further suppressed by bosentan. Therapeutic outcomes were compared as to hemodynamics， pulmonary vascular pathology， and survival.Treatment with VIP， every Other day for 3 weeks， begun on the same day as MCT， almost totally prevented PAH pathology， and eliminated mortality for 45 days. Begun 3 weeks after MCT， however， VIP only partially reversed PAH pathology， though more effectively than bosentan. Combined therapy with both drugs fully reversed the pathology， while preventing mortality for at least 45 days.[3].Animal Model:Sprague Dawley rats；Dosage:Bosentan (HY-A0013 ) 300 mg/kg， Aviptadil 500 μg/kg；Administration:Bosentan (HY-A0013 ) Oral gavage (p.o); Aviptadil Intraperitoneal injection (i.p)；Result:Starting on day 21， the rats treated with Bosentan or Aviptadil alone had a 29% reduction in mortality (P< 0.0001). No death was observed in the rats during the same time period. |
| 数据来源文献 | [1]. Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure (COVID-AIV) [2]. Jian Hu， et al. Novel Targets of Drug Treatment for Pulmonary Hypertension. Am J Cardiovasc Drugs [3]. Hamidi SA， et al. VIP and endothelin receptor antagonist: an effective combination against experimental pulmonary arterial hypertension. Respir Res. 2011;12(1):141. Published 2011 Oct 26. [4]. Nagahiro I， et al. Vasoactive intestinal peptide ameliorates reperfusion injury in rat lung transplantation. J Heart Lung Transplant. 1998;17(6):617-621. |
| 单位 | 瓶 |
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IA7470 阿肽地尔 Peptides 索莱宝
￥1190 - 3490
