IC5410 氯化十六烷基吡啶 抑制剂/拮抗剂/激动剂 索莱

使用本产品的案例（仅供参考）

In Vitro

Cell（MC3T3-E1 cells；10%  cetylpyridinium chloride；562 nm）

MC3T3-E1 cells were seeded in a 12-well plate at a density of 2 ×10⁴/mL, and cultured with osteogenic induction extracts, which contained sample extracts, 10 mM β-glycerophosphate, 0.1 mM dexamethasone (Solarbio, China) and 50 μg/mL vitamin C (Solarbio, China).  After 7 days of incubation, cells were lysed using inhibitorfree Western and IP cell lysate and total protein was extracted.  The bicinchoninic acid protein assay kit was used to determine the total protein content.  The ALP detection kit was applied to detect the ALP activity of MC3T3- E1.  The results were expressed in U per mg of total protein.  Moreover, MC3T3-E1 cells were stained using an ALP staining kit to evaluate the formation of calcified nodules.  Alizarin red (Solarbio, China) was used to stain MC3T3-E1 after 21 days of culturing.  Then, mineralized nodules were dissolved using 10% of cetylpyridinium chloride (Solarbio, China) and measured the absorbance at 562 nm.

来源文献：Zhang Z, Liu A, Fan J, Wang M, Dai J, Jin X, Deng H, Wang X, Liang Y, Li H, Zhao Y, Wen P, Li Y. A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn-1Mg porous scaffolds as biodegradable bone implants.  Bioact Mater. 2023 Apr 28;27:488-504.  doi: 10.1016/j.bioactmat.2023.04.017.  PMID: 37180641;  PMCID: PMC10173180.

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标题:Influence of porous tantalum scaffold pore size on osteogenesis and osteointegration: A comprehensive study based on 3D-printing technology

成员:Luo C; Wang C; Wu X; Xie X; Wang C; Zhao C; Zou C;

论文因子:7.9 发表期刊:Mater Sci Eng C Mater Biol Appl pmid:34579901

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标题:Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis

成员:Yao XW; Liu HD; Ren MX; Li TL; Jiang WK; Zhou Z; L

论文因子:2.8 发表期刊:Mol Biol Rep pmid:36243792

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标题:A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn-1Mg porous scaffolds as biodegradable bone implants

成员:Zhang Z; Liu A; Fan J; Wang M; Dai J; Jin X; Deng

论文因子:18.9 发表期刊:Bioact Mater pmid:37180641

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标题:A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn-1Mg porous scaffolds as biodegradable bone implants

成员:Zhang Z; Liu A; Fan J; Wang M; Dai J; Jin X; Deng

论文因子:18.9 发表期刊:Bioact Mater pmid:37180641

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标题:Construction of a layer-by-layer self-assembled rosemarinic acid delivery system on the surface of CFRPEEK implants for enhanced anti-inflammatory and osseointegration activities

成员:Shanshan Zhao, Xingyu Zhou, Junbo Dang, Yilong Wang, Junhui Jiang, Tianhao Zhao, Dahui Sun, Chen Chen, Xin Dai, Yan Liu, Mei Zhang

论文因子:7 发表期刊:Journal of Materials Chemistry B pmid:38411199

基本信息
CAS	No.123-03-5
中文名称	氯化十六烷基吡啶
英文名称	Cetylpyridinium chloride
别名	西吡氯铵;氯化十六烷吡啶;氯化十六烷基吡啶翁;HGP6;1-十六烷基吡啶氯化物;Hexadecylpyridiniumchloride;Chondroitinhydrochloride;
分子式	C21H38ClN
分子量	339.99
溶解性	Soluble in Water ≥5mg/mL(Need ultrasonic)
纯度	≥98%
外观(性状)	White to off-white Solid
储存条件	Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
EC	EINECS 204-593-9
MDL	MFCD00011731
SMILES	CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1.[Cl-]
InChIKey	YMKDRGPMQRFJGP-UHFFFAOYSA-M
InChI	InChI=1S/C21H38N.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-22-20-17-15-18-21-22;/h15，17-18，20-21H，2-14，16，19H2，1H3;1H/q+1;/p-1
PubChem CID	31239
靶点	Others
通路	Others
背景说明	Cetylpyridinium chloride是一种阳离子季铵化合物，具有广谱的抗菌活性。Cetylpyridinium chloride可用于在茜素红对细胞矿化染色后，使用Cetylpyridinium chloride对矿化结节进行半定量分析。
单位	瓶