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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
DIM-C-pPhOCH3
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
33985-68-1
- 规格：
50mg/25mg/10mg/5mg/1mg
| 规格： | 50mg | 产品价格： | ￥2990.0 |
|---|---|---|---|
| 规格： | 25mg | 产品价格： | ￥1990.0 |
| 规格： | 10mg | 产品价格： | ￥1190.0 |
| 规格： | 5mg | 产品价格： | ￥790.0 |
| 规格： | 1mg | 产品价格： | ￥310.0 |
| 基本信息 | |
| CAS | No.33985-68-1 |
| 英文名称 | DIM-C-pPhOCH3 |
| 别名 | DIM-C-pPhOCH3 |
| 分子式 | C24H20N2O |
| 分子量 | 352.43 |
| 溶解性 | Soluble in DMSO ≥5mg/mL |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01217840 |
| SMILES | COC1=CC=C(C=C1)C(C2=CNC3=CC=CC=C32)C4=CNC5=CC=CC=C54 |
| InChIKey | ZCCMKJAXOIFTHH-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H20N2O/c1-27-17-12-10-16(11-13-17)24(20-14-25-22-8-4-2-6-18(20)22)21-15-26-23-9-5-3-7-19(21)23/h2-15，24-26H，1H3 |
| PubChem CID | 11371604 |
| 靶点 | Nur77 |
| 通路 | Immunology & Inflammation |
| 背景说明 | DIM-C-pPhOCH3 是一种 Nur77 激动剂。 |
| 生物活性 | DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα， Nur77) is an orphan nuclear receptor.[1] |
| In Vitro | DIM-C-pPhOCH3 decreases survival and induces apoptosis in RKO colon cancer cells， and this is accompanied by induction of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) protein. DIM-C-pPhOCH3 also induces Nur77-independent apoptosis. DIM-C-pPhOCH3 (10 μM) inhibits cell growth after treatment for 24， 48， or 72 h， and the maximum inhibitory response is observed after 72 h， where there is considerable cell detachment and dead cells. The growth-inhibitory effects observed for DIM-C-pPhOCH3 after 72 h are also accompanied by several markers of apoptosis， including PARP cleavage and cleavage of caspase-3， caspase-9， and caspase-8. PARP cleavage is also observed after treatment of RKO cells for 48 h with DIM-C-pPhOCH3[1]. |
| 细胞实验 | DIM-C-pPhOCH3 (25 mg/kg/d) also inhibits tumor growth in athymic nude mice bearing RKO cell xenografts. The effects of DIM-C-pPhOCH3 (25 mg/kg/d) on colon tumor growth are also investigated in athymic nude mice bearing RKO cell xenografts. Treatment with the DIM-C-pPhOCH3 significantly decreases tumor volumes and final tumor weights compared with corn oil controls[1]. |
| 细胞实验 | RKO cells are treated with DMSO or 12.5 μM DIM-C-pPhOCH3 for 2 and 6 h. RNA is isolated for the reverse transcription-PCR (RT-PCR) experiment and analyzed for gene expression， and three replicates are determined for each time point and the DMSO control. The microarray data are analyzed[1]. |
| 动物实验 | Mice[1]:Male athymic nude mice (Foxn1nu， ages 7-8 weeks) are used. The mice are housed and maintained in laminar flow cabinets under specific pathogen-free conditions. A xenograft is established by s.c. injection of in vitro cultured RKO cells (5×106 per 150 μL) into the flanks of individual mice. Tumors are allowed to grow for 4 days until tumors are palpable. Mice are then randomized into two groups of six mice per group and dosed by oral gavage with either corn oil or 25 mg/kg/d DIM-C-pPhOCH3 for 21 days. The mice are weighed， and tumor size is measured[1]. |
| 数据来源文献 | [1]. Cho SD， et al. Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Res. 2007 Jan 15;67(2):674-83. |
| 单位 | 瓶 |
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