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- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Glycodeoxycholic Acid
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
360-65-6
- 规格：
500mg/100mg/25mg/50mg/10mg
| 规格： | 500mg | 产品价格： | ￥920.0 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ￥370.0 |
| 规格： | 25mg | 产品价格： | ￥190.0 |
| 规格： | 50mg | 产品价格： | ￥268.0 |
| 规格： | 10mg | 产品价格： | ￥125.0 |
是一种具有生物活性的化合物。
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Aqueous Extract of Lycium ruthenicum Murray Attenuates Neuroinflammation in C57BL/6J Mice Induced by High-Fat and High-Fructose Diet Through Regulating Gut Microbiota and Bile Acid Metabolism
成员:Xia Fan, Wei Dong, Yujie Huang, Yifan Shu, Yamei Yan, Jia Mi, Lu Lu, Xiaoxiong Zeng, Youlong Cao
论文因子:4.7 发表期刊:Foods pmid:39682885
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy
成员:Tang Bo, Tang Li, Li Shengpeng, Liu Shuang, He Jialin, Li Pan, Wang Sumin, Yang Min, Zhang Longhui, Lei Yuanyuan, Tu Dianji, Tang Xuefeng, Hu Hua, Ouyang Qin, Chen Xia, Yang Shiming
论文因子:16.6 发表期刊:Nature Communications pmid:36894566
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:The polysaccharides from Auricularia auricula alleviate non-alcoholic fatty liver disease via modulating gut microbiota and bile acids metabolism
成员:Yifan Shu, Yujie Huang, Wei Dong, Xia Fan, Yi Sun, Guijie Chen, Xiaoxiong Zeng, Hong Ye
论文因子:8.2 发表期刊:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES pmid:37399869
| 基本信息 | |
| CAS | No.360-65-6 |
| 中文名称 | 甘氨脱氧胆酸 |
| 英文名称 | Glycodeoxycholic Acid |
| 别名 | N-(3Α,12Α-二羟基-24-氧胆)甘氨酸 |
| 分子式 | C26H43NO5 |
| 分子量 | 449.62 |
| 溶解性 | Soluble in DMSO |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00150922 |
| SMILES | O=C(O)CNC(CC[C@H]([C@H]1CC[C@@]2([H])[C@]3([H])CCC4C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)C)=O |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 据报道，Glycodeoxycholic Acid是一种内源性代谢产物，存在于黑链霉菌、布氏锥虫和隐单胞菌中，可诱导阻塞性胆汁淤积症患者的肝细胞坏死和自噬。 |
| 生物活性 | Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans， Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis[1][2][3]. |
| In Vitro | We found that GCDC promoted chemoresistance in HCC cells by down-regulating and up-regulating the expression of apoptotic and anti-apoptotic genes， respectively. Furthermore， GCDC induced the EMT phenotype and stemness in HCC cells and activated the STAT3 signaling pathway.[1]。Cell Viability Assay[1]:Cell Line:Huh7， LM3;Concentration:200 μM;Incubation Time:24， 48 h;Result:Increased cell viability treated with 5-FU and cisplatin.Western Blot Analysis[1]:Cell Line:Huh7， LM3;Concentration:200 μM;Incubation Time: 24， 48 h;Result:Suppressed the expression of apoptotic genes and increased anti-apoptotic genes.Promoted the expression of Sox2， Sox9， Nanog and CD133.Down-regulated the level of E-cadherin and up-regulated vimentin.Decreased the levels of SOCS2， SOCS5， PTPN1 and PTPN11. |
| 细胞实验 | GDOC injections (initial dose of 11.20 mg/kg) were administered in an escalating manner at specific time points. The injection was given along the bilio - pancreatic duct， followed by measurement of vital signs， serum amylase - lipase， TNF - α， procalcitonin， oxidative stress parameters， and microscopic and macroscopic findings.The results indicated that acute pancreatitis occurred following induction with low - dose GDOC. Serum amylase and lipase levels increased with subsequent GDOC injections. Blood pressure and heart rate were elevated， indicating abdominal pain. Changes in TNF - α， procalcitonin， and oxidative stress values showed active inflammation. We observed histologic features of pancreatitis and as the dose increased， vasodilation of the splanchnic vasculatures was observed.[3]。Animal Model:Experimental macaque model[3];Dosage: 11.20 mg/kg;Administration:injected along the biliopancreatic duct;Result:Increased the levels of Serum amylase and lipase.Elevated Blood pressure and heart rate. |
| 数据来源文献 | [1]. Shi C， et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555. [2]. Vaz AR， et al. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem. 2010 Jan;112(1):56-65. [3]. Fauzi A， et al. Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina. J Med Primatol. 2022 Jun;51(3):134-142. doi: 10.1111/jmp.12577. Epub 2022 Mar 20. PMID: 35306662; PMCID: PMC9310849. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Aqueous Extract of Lycium ruthenicum Murray Attenuates Neuroinflammation in C57BL/6J Mice Induced by High-Fat and High-Fructose Diet Through Regulating Gut Microbiota and Bile Acid Metabolism
成员:Xia Fan, Wei Dong, Yujie Huang, Yifan Shu, Yamei Yan, Jia Mi, Lu Lu, Xiaoxiong Zeng, Youlong Cao
论文因子:4.7 发表期刊:Foods pmid:39682885
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy
成员:Tang Bo, Tang Li, Li Shengpeng, Liu Shuang, He Jialin, Li Pan, Wang Sumin, Yang Min, Zhang Longhui, Lei Yuanyuan, Tu Dianji, Tang Xuefeng, Hu Hua, Ouyang Qin, Chen Xia, Yang Shiming
论文因子:16.6 发表期刊:Nature Communications pmid:36894566
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:The polysaccharides from Auricularia auricula alleviate non-alcoholic fatty liver disease via modulating gut microbiota and bile acids metabolism
成员:Yifan Shu, Yujie Huang, Wei Dong, Xia Fan, Yi Sun, Guijie Chen, Xiaoxiong Zeng, Hong Ye
论文因子:8.2 发表期刊:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES pmid:37399869
|998894|gb|S78179.1|S78179 Oryctolagus cuniculus type XII... 32 0.037 gi|31072033|gb|AC122153.4| Oryctolagus cuniculus clone LB1-... 28 0.58 gi|1496|emb|X52496.1|OCCAATP Rabbit mRNA for calcium ATPase 28 0.58 gi|1468|emb|X02814.1|OCATPDR Rabbit mRNA
2F+DwTquooTcizAj6Sh40arj1e+iWJ2ispgsbT801bWi9OaaVDQ0u7N9Rf22Q7je3ypEkT/aXtAx/4gHh20RbetchuWXizve3YY/3L0LGHHqt8Cva+97zf/vEfvyYb4imWXpTxLz8m4rvgjodswc3X26Xnn2o3LbjZPv/Fv5GGuGa33/ZzO2n2HD17NAEWeUXwmQh44uy32U+uutL+69e+6jjedfsddvSxx3m8xNNFQ67wipqQKHyESZ35
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