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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at 2-8℃，2 years
- 保质期：
Store at 2-8℃，2 years
- 英文名：
Carvacrol
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
499-75-2
- 规格：
200mg/100mg/20mg
| 规格： | 200mg | 产品价格： | ￥736.0 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ￥490.0 |
| 规格： | 20mg | 产品价格： | ￥220.0 |
Carvacrol 是唇形科植物中的单萜酚类，具有抗氧化、抗炎、抗癌活性。Carvacrol 可导致 G0/G1 细胞周期停滞，下调 Notch-1 和 Jagged-1，诱导凋亡。
| 基本信息 | |
| CAS | No.499-75-2 |
| 中文名称 | 香荆芥酚 |
| 英文名称 | Carvacrol |
| 别名 | cymophenol;O-Thymol;Karvakrol;香芹酚 |
| 分子式 | C10H14O |
| 分子量 | 150.22 |
| 溶解性 | Soluble in DMSO |
| 纯度 | HPLC≥98% |
| 外观(性状) | Colorless to light yellow Liquid |
| 储存条件 | Store at 2-8℃，2 years |
| 密度 | 0.976g/mL |
| EC | EINECS 207-889-6 |
| MDL | MFCD00002236 |
| SMILES | CC(C)C1=CC(O)=C(C)C=C1 |
| InChIKey | RECUKUPTGUEGMW-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3 |
| PubChem CID | 10364 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | Carvacrol 是唇形科植物中的单萜酚类,具有抗氧化、抗炎、抗癌活性。Carvacrol 可导致 G0/G1 细胞周期停滞,下调 Notch-1 和 Jagged-1,诱导凋亡。 |
| 生物活性 | Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.[1-2] |
| In Vitro | Carvacrol(CVC)possesses weak antioxidant and cytotoxic activity in cultured primary rat neurons. In addition，Carvacrol has weak antioxidant properties and little anticancer potentials in rat N2a neuroblastoma cell line[1]. Carvacrol is a novel inhibitor of transient receptor potential(TRP)channels in drosophila and mammalian. In human hepatoma HepG2 cells，Carvacrol induces cell apoptosis by selectively decreasing phosphorylation of extracellular signal-regulated kinase 1/2(ERK1/2)and P38; In human macrophage-like U937 cells，in response to lipopolysaccharide treatment，Carvacrol activates peroxisome proliferator-activated receptors(PPAR alpha and gamma)and suppresses cyclooxygenase-2(COX-2)mRNA and protein expression[2]. |
| 细胞实验 | Carvacrol has the ability to protect liver against ischemia/reperfusion injury in rats. In the central nervous system，Carvacrol is regarded as a potential drug for Alzheimer's disease due to its inhibitory effect on acetylcholinesterase(AChE)activity by using phenolic hydroxyl group of carvacrol to bind to AChE and leading to a loss of function of AChE. In addition，Carvacrol is found to have an antidepressant-like effect in mice by affecting the dopaminergic system. Dietary carvacrol supplementation prevents high fat diet-induced obesity by modulating gene expressions that lead to adipogenesis and inflammation. Carvacrol crosses the blood-brain barrier easily and rapidly[2]. |
| 细胞实验 | The cells are seeded in 48-well plates. Cells are incubated at 37 °C in a humidified 5 % CO2/95 % air mixture and treated with carvacrol at different concentrations(10，25，50，100，200 and 400 mg/L)for 24 h. MTT substrate solution is used. Briefly，MTT is added to the cell cultures for 3 h. Formed formazan crystals are dissolved in dimethyl sulfoxide(DMSO)，MTT is added to the cell cultures for 3 h. Formed formazan crystals are dissolved in dimethyl sulfoxide(DMSO).[1] |
| 动物实验 | Animal Models: Male ICR mice; Dosages: 50 mg/kg; Administration: i.c.v.[2] |
| 数据来源文献 | [1] Elanur Ayd n， et al. Cytotechnology. 2014， 66(1): 149–157. [2] Yu H， et al. PLoS One. 2012， 7(3):e33584. |
| 单位 | 瓶 |
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文献和实验CDllb 常用单克隆抗体或代号：Mol，OKM1；(Macl，CR3，整合素αM) 主要表达细胞：G，M，T， B， DC， NK，Mac[AS] 分子质量(kDa)和结构：gp170(整合素α) 功 能：iC3b和Fs受体，与ICAM-l和X因子结合，黏附，调理吞噬；结合JAM-3 CDllc 常用单克隆抗体或代号：LeuM乳(CR4．整合素αX) 主要表达细胞：M，G，B
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