- ￥86 - 1778
- Solarbio
- 北京
- IH0310
- 2025年12月26日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
3-Hydroxy-4-methoxycinnamic acid
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
537-73-5
- 规格：
1g/500mg/25mg/10mg/5mg/100mg/50mg
| 规格： | 1g | 产品价格： | ￥1778.0 |
|---|---|---|---|
| 规格： | 500mg | 产品价格： | ￥1204.0 |
| 规格： | 25mg | 产品价格： | ￥250.0 |
| 规格： | 10mg | 产品价格： | ￥134.0 |
| 规格： | 5mg | 产品价格： | ￥86.0 |
| 规格： | 100mg | 产品价格： | ￥490.0 |
| 规格： | 50mg | 产品价格： | ￥354.0 |
是肉桂酸衍生物，结合并激活 α1-ADr能受体，增强 β-内啡肽的分泌并增加体外葡萄糖的使用。
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:An integrated strategy for the systematic chemical characterization of Salvianolate lyophilized injection using four scan modes based on the ultra-high performance liquid chromatography-triple quadrupole-linear ion trap mass spectrometry
成员:Yaqing Guo, Rui Mao, Yuanyuan Zhang, Rongrong Li, Patrick Kwabena Oduro, Dandan Si, Lifeng Han, Yuhong Huang, Guixiang Pan
论文因子:3.571 发表期刊:JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS pmid:35468503
| 基本信息 | |
| CAS | No.537-73-5 |
| 中文名称 | 异阿魏酸 |
| 英文名称 | 3-Hydroxy-4-methoxycinnamic acid |
| 别名 | Hesperetate;Isoferulate |
| 分子式 | C10H10O4 |
| 分子量 | 194.18 |
| 溶解性 | Soluble in DMSO |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-676-0 |
| MDL | MFCD00004391 |
| SMILES | O=C(O)/C=C/C1=CC=C(OC)C(O)=C1 |
| InChIKey | QURCVMIEKCOAJU-HWKANZROSA-N |
| InChI | InChI=1S/C10H10O4/c1-14-9-4-2-7(6-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+ |
| PubChem CID | 736186 |
| 靶点 | Adrenergic Receptor |
| 通路 | Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| 背景说明 | 3-Hydroxy-4-methoxycinnamic acid是肉桂酸衍生物,结合并激活 α1-ADr能受体,增强 β-内啡肽的分泌并增加体外葡萄糖的使用。 |
| 生物活性 | Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 μM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use. Isoferulic acid also has anti-influenza virus activities.[1-2] |
| In Vitro | Isoferulic acid(IFA)is a main active ingredient of the rhizoma of Cimicifuga beracleifolia，which is used frequently in Japanese traditional medicine as an anti-inflammatory drug. It has been revealed that IFA inhibits the production of macrophage inflammatory protein-2(MIP-2)，which is a murine counterpart of the chemokine family that may contribute to the pathogenesis of inflammatory diseases through the chemotactic activity for inflammatory and immune effector cells.[2] |
| 细胞实验 | Isoferulic acid may activate alpha1-adrenoceptors to enhance the secretion of beta-endorphin，which can stimulate the opioid mu-receptors to increase glucose use or/and reduce hepatic gluconeogenesis，resulting in a decrease of plasma glucose in STZ-diabetic rats.[1] IFA administration markedly improved the survival rate and body weight loss of influenza virus-infected mice in a suitable dose range(0.5 mg/day).[2] |
| 动物实验 | Mice were infected by intranasal inoculation of influenza virus under ether anesthesia. The IFA or DX was given by oral administration once daily for 4 days after infection. After infection，the survival rate and the change in body weight were daily monitored.[2] |
| 数据来源文献 | [1]. Liu IM， et al. Mediation of beta-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther. 2003 Dec;307(3):1196-204. [2]. Sakai S， et al. Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice. Mediators Inflamm. 2001 Apr;10(2):93-6. |
| 单位 | 瓶 |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:An integrated strategy for the systematic chemical characterization of Salvianolate lyophilized injection using four scan modes based on the ultra-high performance liquid chromatography-triple quadrupole-linear ion trap mass spectrometry
成员:Yaqing Guo, Rui Mao, Yuanyuan Zhang, Rongrong Li, Patrick Kwabena Oduro, Dandan Si, Lifeng Han, Yuhong Huang, Guixiang Pan
论文因子:3.571 发表期刊:JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS pmid:35468503
2F+DwTquooTcizAj6Sh40arj1e+iWJ2ispgsbT801bWi9OaaVDQ0u7N9Rf22Q7je3ypEkT/aXtAx/4gHh20RbetchuWXizve3YY/3L0LGHHqt8Cva+97zf/vEfvyYb4imWXpTxLz8m4rvgjodswc3X26Xnn2o3LbjZPv/Fv5GGuGa33/ZzO2n2HD17NAEWeUXwmQh44uy32U+uutL+69e+6jjedfsddvSxx3m8xNNFQ67wipqQKHyESZ35
hybridization and differential display. Int J Cancer, 1997, 71：1035-1044. 16 Silva ID, Salicioni AM, Russo IH, et al. Tamoxifen down-regulates CD36 messenger RNA levels in normal and neoplastic human breast tissues. Cancer Res, 1997, 57： 378-381. 17 Yang X
技术资料暂无技术资料 索取技术资料
