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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Asiatic acid
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
464-92-6
- 规格：
100mg/50mg/10mM*1mL in DMSO/20mg/10mg/5mg
| 规格： | 100mg | 产品价格： | ￥740.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥490.0 |
| 规格： | 10mM*1mL in DMSO | 产品价格： | ￥160.0 |
| 规格： | 20mg | 产品价格： | ￥360.0 |
| 规格： | 10mg | 产品价格： | ￥240.0 |
| 规格： | 5mg | 产品价格： | ￥150.0 |
是一种五环三萜，可诱导黑色素瘤细胞的凋亡。还具有抗炎活性。
| 基本信息 | |
| CAS | No.464-92-6 |
| 中文名称 | 积雪草酸 |
| 英文名称 | Asiatic acid |
| 别名 | Dammarolic acid |
| 分子式 | C30H48O5 |
| 分子量 | 488.7 |
| 溶解性 | Soluble in DMSO |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 482-720-9 |
| MDL | MFCD00238541 |
| SMILES | O=C([C@]12CC[C@@H](C)[C@H](C)[C@@]1([H])C3=CC[C@]4([H])[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@]5([H])CC[C@@]4(C)[C@]3(C)CC2)O |
| InChIKey | JXSVIVRDWWRQRT-UYDOISQJSA-N |
| InChI | InChI=1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s |
| PubChem CID | 119034 |
| 靶点 | p38MAPK |
| 通路 | MAPK |
| 背景说明 | 是一种五环三萜,可诱导黑色素瘤细胞的凋亡。还具有抗炎活性。 |
| 生物活性 | Asiatic acid， a pentacyclic triterpene found in Centella asiatica， induces apoptosis in melanoma cells. Asiatic acid has the potential for skin cancer treatment[1]. Asiatic acid also has anti-inflammatory activities[2]. |
| In Vitro | AA decreased viability and induced apoptosis in human melanoma SK-MEL-2 cells in a time- and dose-dependent manner. AA also markedly increased intracellular reactive oxygen species(ROS)level and enhanced the expression of Bax but not Bcl-2 protein in the cells. In addition，AA-induced activation of caspase-3 activity in a dose-dependent manner.[1] |
| 细胞实验 | Treatment of male ICR mice with AA significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain in the late phase. In the anti-inflammatory test，AA decreased the paw edema at the 4th and 5th h after λ-carrageenan(Carr)administration and increased the activities of catalase(CAT)，superoxide dismutase(SOD)，and glutathione peroxidase(GPx)in the liver tissue. AA decreased the nitric oxide(NO)，tumor necrosis factor-α(TNF-α)，and interleukin-1β(IL-1β)levels on serum level at the 5th h after Carr injection. Western blotting revealed that AA decreased Carr-induced inducible nitric oxide synthase(iNOS)，cyclooxygenase(COX-2)，and nuclear factor-κB(NF-κB)expressions at the 5th h in the edema paw. An intraperitoneal(i.p.)injection treatment with AA also diminished neutrophil infiltration into sites of inflammation as did indomethacin(Indo).[2] |
| 数据来源文献 | [1]. Park BC， et al. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 2005 Jan 31;218(1):81-90. [2]. Huang SS， et al. Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. Evid Based Complement Alternat Med. 2011;2011:895857. |
| 单位 | 瓶 |
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IA1010 积雪草酸 抑制剂/拮抗剂/激动剂 索莱宝
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