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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
N-Acetylneuraminic acid
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
131-48-6
- 规格：
1g/500mg/100mg/20mg
| 规格： | 1g | 产品价格： | ￥690.0 |
|---|---|---|---|
| 规格： | 500mg | 产品价格： | ￥580.0 |
| 规格： | 100mg | 产品价格： | ￥490.0 |
| 规格： | 20mg | 产品价格： | ￥200.0 |
是一个在细胞膜的糖蛋白和哺乳细胞神经节甘脂的糖脂上普遍存在的唾液酸单糖，在神经传递， 白细胞血管渗出，病毒或细菌感染起着生物作用。
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:HPLC-QQQ-MS/MS-based authentication and determination of free and bound sialic acids content in human, bovine, sheep, goat milk, and infant formula
成员:Qingyan Chen, Abdul Mueed, Liuying Zhu, Zeyuan Deng, Han Peng, Hongyan Li, Bing Zhang
论文因子:3.2 发表期刊:JOURNAL OF FOOD SCIENCE pmid:38847763
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Sialic acids as attachment factors in mosquitoes mediating Japanese encephalitis virus infection
成员:Yi He, Chang Miao, Shiping Yang, Changhao Xu, Yuwei Liu, Xi Zhu, Yiping Wen, Rui Wu, Qin Zhao, Xiaobo Huang, Qigui Yan, Yifei Lang, Shan Zhao, Yiping Wang, Xinfeng Han, Sanjie Cao, Yajie Hu, Senyan Du
论文因子:4 发表期刊:JOURNAL OF VIROLOGY pmid:38634598
| 基本信息 | |
| CAS | No.131-48-6 |
| 中文名称 | 唾液酸 |
| 英文名称 | N-Acetylneuraminic acid |
| 别名 | 唾液酸;唾液酸;N-乙酰基神经氨酸;醋纽拉酸;N-乙酰甘露糖胺ACE酸;N-乙酰涎酸;氧-唾液酸;N-乙酰-神经氨(糖)酸 |
| 分子式 | C11H19NO9 |
| 分子量 | 309.27 |
| 溶解性 | Soluble in Water ≥10mg/mL |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-023-1 |
| MDL | MFCD00006620 |
| SMILES | OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](NC(C)=O)[C@@H](O)CC(C(O)=O)=O |
| InChIKey | SQVRNKJHWKZAKO-PFQGKNLYSA-N |
| InChI | InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11-/m0/s1 |
| PubChem CID | 445063 |
| 靶点 | Endogenous Metabolite |
| 通路 | Others |
| 背景说明 | 是一个在细胞膜的糖蛋白和哺乳细胞神经节甘脂的糖脂上普遍存在的唾液酸单糖,在神经传递, 白细胞血管渗出,病毒或细菌感染起着生物作用。 |
| 生物活性 | N-Acetylneuraminic acid (Neu5Ac)， a type of sialic acid， has close links with cholesterol metabolism and is often used as a biomarker in evaluating the risk of cardiovascular diseases. [2] |
| 细胞实验 | Administration of NANA by both oral and i.p. routes resulted in significantly more cerebral and cerebellar ganglioside and glycoprotein NANA than did glucose injection(with the exception of cerebellar glycoprotein NANA after NANA intubation).[1] Neu5Ac prevented HFD-induced hyperlipidemia and associated hypercoagulation in rats through regulation of lipid-related and coagulation-related genes and，by extension，induced metabolite and protein changes.[2] |
| 动物实验 | Rat pups were administered N-acetylneuraminic acid(NANA)by i.p. injection or via a feeding catheter for eight consecutive days beginning on d 14 of life. All pups were given the identical dose: 1.0 mg on d 1 and 2 and 1.2 mg on the remaining days，or approximately 20 mg/kg body weight per day. A control group was injected i.p. with glucose instead of NANA. On the morning of d 25，pups were decapitated，and the heads were frozen immediately in liquid nitrogen. The brains were later dissected and analyzed for both cerebral and cerebellar ganglioside and glycoprotein NANA.[1]Sprague Dawley male rats were divided into five different groups and fed with HFD alone，HFD low-dose Neu5Ac，HFD high-dose Neu5Ac，HFD simvastatin(10mg/kg day)，and normal pellet alone. Food was given ad libitum while body weight of rats was measured weekly. After 12 weeks of intervention，rats were sacrificed and serum and tissue samples were collected for biochemistry and gene expression analysis，respectively.[2] |
| 数据来源文献 | [1]. Carlson SE， House SG. Oral and intraperitoneal administration of N-acetylneuraminic acid: effect on rat cerebral and cerebellar N-acetylneuraminic acid. J Nutr. 1986 May;116(5):881-6. [2]. |
| 单位 | 支 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:HPLC-QQQ-MS/MS-based authentication and determination of free and bound sialic acids content in human, bovine, sheep, goat milk, and infant formula
成员:Qingyan Chen, Abdul Mueed, Liuying Zhu, Zeyuan Deng, Han Peng, Hongyan Li, Bing Zhang
论文因子:3.2 发表期刊:JOURNAL OF FOOD SCIENCE pmid:38847763
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Sialic acids as attachment factors in mosquitoes mediating Japanese encephalitis virus infection
成员:Yi He, Chang Miao, Shiping Yang, Changhao Xu, Yuwei Liu, Xi Zhu, Yiping Wen, Rui Wu, Qin Zhao, Xiaobo Huang, Qigui Yan, Yifei Lang, Shan Zhao, Yiping Wang, Xinfeng Han, Sanjie Cao, Yajie Hu, Senyan Du
论文因子:4 发表期刊:JOURNAL OF VIROLOGY pmid:38634598
2F+DwTquooTcizAj6Sh40arj1e+iWJ2ispgsbT801bWi9OaaVDQ0u7N9Rf22Q7je3ypEkT/aXtAx/4gHh20RbetchuWXizve3YY/3L0LGHHqt8Cva+97zf/vEfvyYb4imWXpTxLz8m4rvgjodswc3X26Xnn2o3LbjZPv/Fv5GGuGa33/ZzO2n2HD17NAEWeUXwmQh44uy32U+uutL+69e+6jjedfsddvSxx3m8xNNFQ67wipqQKHyESZ35
抗原决定簇，虽与体液中的抗原决定簇糖链结构相同，但连接的骨架不同。红细胞上的糖链是通过神经鞘氨醇与脂肪酸结合在一起，而不是与蛋白质结合在一起，所以红细胞上的ABH抗原是糖脂而不是糖蛋白。 MN·P及I血型的抗原决定簇也是碳水化合物。Rh抗原的决定簇可能是蛋白质，因为红细胞经硫氢化物、脲素及蛋白酶等物处理后，Rh活性即行消失。 有一些血型抗体，如抗IH，抗IA，抗IB，抗IP1 等，只与带有I抗原及另外一个抗原的细胞发生反应，而不与其中只有一个抗原的细胞发生反应。说明
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