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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
L-Ornithine Hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
3184-13-2
- 规格：
500mg/100mg
| 规格： | 500mg | 产品价格： | ￥790.0 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ￥490.0 |
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Safety evaluation and application of lactic acid bacteria and yeast strains isolated from Sichuan broad bean paste
成员:Lu Feng, Jinhong Gu, Linjie Guo, Guangqing Mu, Yanfeng Tuo
论文因子:3.553 发表期刊:Food Science & Nutrition pmid:36789042
| 基本信息 | |
| CAS | No.3184-13-2 |
| 中文名称 | L-鸟氨酸盐酸盐 |
| 英文名称 | L-Ornithine Hydrochloride |
| 别名 | (S)-2;5-Diaminopentanoic acid;L-2;5-二氨基戊酸盐酸盐;L-鸟氨酸单盐酸盐;鸟氨酸盐酸盐;L-盐酸鸟氨酸;L-鸟粪氨基酸盐酸盐;L(+)-Ornithine hydrochloride |
| 分子式 | C5H13ClN2O2 |
| 分子量 | 168.62 |
| 溶解性 | Soluble in Water |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00064562 |
| SMILES | C(CC(C(=O)O)N)CN.Cl |
| InChIKey | GGTYBZJRPHEQDG-WCCKRBBISA-N |
| InChI | InChI=1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H，1-3，6-7H2，(H，8，9);1H/t4-;/m0./s1 |
| PubChem CID | 76654 |
| 背景说明 | 是一种非蛋白源性氨基酸，具有肾脏保护活性。 |
| 生物活性 | L-Ornithine hydrochloride is a non-proteinogenic amino acid， is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective[1][2]. |
| In Vitro | We used human kidney 2 (HK2) cells， a PT cell line， and performed Ca2+ imaging and electrophysiological experiments to show that l - ornithine has a concentration - dependent effect on CaSR activation.We further demonstrate that the operation of CaSR activated Ca2+ signaling in HK - 2 cells mediated by the transient receptor potential canonical (TRPC) dependent receptor - operated Ca2+ entry (ROCE) using pharmacological and siRNA inhibitors.Since PT cells are vulnerable to ROS， we simulated such deleterious effects using genetically encoded peroxide - induced ROS production (HyperRed indicator) to show that the l - ornithine - induced ROCE mediated [Ca2+]i signaling protects from ROS production.Furthermore， we performed cell viability， necrosis and apoptosis assays， and mitochondrial oxidative gene expression to establish that presence of l - ornithine rescued the ROS - induced damage in HK - 2 cells.Moreover， l - ornithine - activation of CaSR can reverse ROS production and apoptosis via mitogen - activated protein kinase p38 activation. [2]。 |
| 数据来源文献 | [1]. Demura S， et al. Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise. Eur J Appl Physiol. 2011 Nov;111(11):2837-43. [2]. Shin S， et al. l-ornithine activates Ca2+ signaling to exert its protective function on human proximal tubular cells. Cell Signal. 2020 Mar;67:109484. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Safety evaluation and application of lactic acid bacteria and yeast strains isolated from Sichuan broad bean paste
成员:Lu Feng, Jinhong Gu, Linjie Guo, Guangqing Mu, Yanfeng Tuo
论文因子:3.553 发表期刊:Food Science & Nutrition pmid:36789042
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