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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20℃，2 years
- 保质期：
Powder: -20℃，2 years
- 英文名：
α-Carotene
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
7488-99-5
- 规格：
1mg
| 基本信息 | |
| CAS | No.7488-99-5 |
| 中文名称 | α-胡萝卜素 |
| 英文名称 | α-Carotene |
| 分子式 | C40H56 |
| 分子量 | 536.87 |
| 溶解性 | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic) |
| 纯度 | HPLC≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder: -20℃，2 years |
| MDL | MFCD00136012 |
| SMILES | CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2C(=CCCC2(C)C)C)C)C |
| InChIKey | ANVAOWXLWRTKGA-NTXLUARGSA-N |
| InChI | InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37，7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38，9)10/h11-14，17-23，25-28，37H，15-16，24，29-30H2，1-10H3/b12-11+，19-13+，20-14+，27-25+，28-26+，31-17+，32-18+，33-21+，34-22+/t37-/m0/s1 |
| PubChem CID | 6419725 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 是维生素 A 的前体，可用于抗转移剂或抗癌药佐剂的相关研究。 |
| 生物活性 | α-Carotene， a precursor of vitamin A， is used as an anti-metastatic agent or as an adjuvant for anti-cancer agents. α-Carotene is isolated from yellow-orange and dark-green vegetables[1][2]. |
| In Vitro | α-Carotene (0.5-2.5 μM; 24 hours) significantly increases protein expression of TIMP-1 and TIMP-2 in a concentration-dependent manner in LLC cells. AC (0.5-2.5 μM) significantly increases PAI-1 protein expression. α-Carotene (2.5 μM) also significantly inhibits integrin β1-mediated phosphorylation of focal adhesion kinase (FAK) which then decreased the phosphorylation of MAPK family[2].α-Carotene (0.5， 1， 2.5 μM; 48 hours) significantly and concentration-dependently inhibits invasion of LLC during 48 h of incubation[2].α-Carotene (0.5， 1， 2.5 μM; 24 hours) significantly decreases activities of MMP-9， -2 and uPA in concentration-dependent manner in LLC cells[2].α-Carotene (2， 5， 10 μM; 7 days) inhibits the proliferation of the human neuroblastoma cell line GOTO in a dose- and time-dependent manner. α-Carotene (5 μM; 48 hours) halts the cell cycle at the G0/G1 phase concomitantly with a reduction in the mRNA expression of the protooncogene N-Myc[3]. |
| 细胞实验 | α-Carotene (5 mg/kg; oral; twice a week; for additional 3 weeks) alone significantly decreases lung metastasis without affecting primary tumor growth[2]. |
| 数据来源文献 | [1]. Bushway， R.J.， et al. Determination of α- and β-carotene in fruit and vegetables by high performance liquid chromatography. Can. Inst. Food Sci. Technol. J. 15(3)， 165-169 (1982). [2]. Liu YZ， et al. Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro， and suppresses lungmetastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice. J Nutr Biochem. 2015 Jun;26(6):607-15. [3]. Murakoshi M， et al. Inhibitory effects of alpha-carotene on proliferation of the human neuroblastoma cell line GOTO. J Natl Cancer Inst. 1989 Nov 1;81(21):1649-52. |
| 单位 | 瓶 |
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文献和实验CDllb 常用单克隆抗体或代号：Mol，OKM1；(Macl，CR3，整合素αM) 主要表达细胞：G，M，T， B， DC， NK，Mac[AS] 分子质量(kDa)和结构：gp170(整合素α) 功 能：iC3b和Fs受体，与ICAM-l和X因子结合，黏附，调理吞噬；结合JAM-3 CDllc 常用单克隆抗体或代号：LeuM乳(CR4．整合素αX) 主要表达细胞：M，G，B
a look from the following website just by clicking "Tyrosine Phosphorylation and Dimerization" http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-43F85YV-2&_user=1111158&_coverDate=06%2F29%2F2001&_rdoc=1&_fmt=full&_orig=search
2 是一种用以表示竞争性拮抗剂作用强度的指标，其意义是能使激动剂提高到原来的 2 倍时，可产生与原来浓度相同效应所需的拮抗剂克分子浓度的负对数 (-log(B)) 。 PA2 的值越大说明拮抗剂的作用越强。 pA2 是拮抗参数 (antagonism parameter) ：当有一定浓度的拮抗药存在时，激动剂增加 2 倍时才能达到原来效应，此时拮抗药的负对数即拮抗参数， pA2 = -log[I] = -logKI 3 、药物作用
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