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- Solarbio
- 北京
- IY0180
- 2026年08月13日
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- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Yatein
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- CAS号：
40456-50-6
- 规格：
5mg/1mg
| 规格： | 5mg | 产品价格： | ¥5940.00 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ¥2390.00 |
| CAS | 40456-50-6 |
| 中文名称 | 亚太因 |
| 英文名称 | Yatein |
| 分子式 | C22H24O7 |
| 分子量 | 400.42 |
| 规格 | 5mg ; 1mg |
| 溶解性 | Soluble in DMSO(Need ultrasonic) |
| 纯度 | ≥95% |
| 级别 | Cell Culture |
| 外观(性状) | Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 | 冷冻运输 |
| SMILES | COC1=CC(=CC(=C1OC)OC)CC2C(COC2=O)CC3=CC4=C(C=C3)OCO4 |
| InChIKey | GMLDZDDTZKXJLU-JKSUJKDBSA-N |
| InChI | InChI=1S/C22H24O7/c1-24-19-9-14(10-20(25-2)21(19)26-3)7-16-15(11-27-22(16)23)6-13-4-5-17-18(8-13)29-12-28-17/h4-5，8-10，15-16H，6-7，11-12H2，1-3H3/t15-，16+/m0/s1 |
| PubChem CID | 442835 |
| 靶点 | HSV-1 |
| 通路 | Anti-infection |
| 背景说明 | Yatein 是一种木质素，具有抗增殖活性。Yatein 能抑制单纯疱疹病毒 1 型 (HSV-1) 的复制。 |
| 生物活性 | Yatein is a lignan isolated from A. chilensis， with antiproliferative activity[1]. Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression[2]. |
| In Vitro | Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells[3].Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells[3].Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization[3].Cell Cycle Analysis[3]：Cell Line:A549 cells， CL1-5 cells；Concentration: 1.25 μM ， 2.5 μM ， 5 μM；Incubation Time:24 hours；Result:Induced cell-cycle arrest at G2/M phase in both cell lines.Western Blot Analysis[3]：Cell Line:A549 cells， CL1-5 cells；Concentration:5 μM；Incubation Time:6 hours， 12 hours；Result:Upregulated the expression of cyclin B1， but not Cdc2 and Cdc25c， induced Cdc2 phosphorylation. |
| In Vivo | Yatein (20 mg/kg; i.p.; five times per week; for 42 days) exhibits in vivo antitumor effects in a human lung adenocarcinoma xenograft mouse model[3].Animal Model: Male NOD/SCID mice (6-8 weeks)， with A549 cells xenograft[3]；Dosage: 20 mg/kg；Administration:Intraperitoneal injection， five times per week， for 42 days；Result:Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation. |
| 数据来源文献 | [1]. Donoso-Fierro C， et al. Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. Pharm Biol. 2015 Mar;53(3):378-85. [2]. Kuo YC， et al. Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res. 2006 Jul;70(3):112-20. [3]. Shang-Tse Ho， et al. Molecular Mechanisms Underlying Yatein-Induced Cell-Cycle Arrest and Microtubule Destabilization in Human Lung Adenocarcinoma Cells. Cancers (Basel). 2019 Sep; 11(9): 1384. |
| 单位 | 瓶 |
| 表格1 | |*|1mg|5mg|10mg|$$|1mM|2.4974mL|12.4869mL|24.9738mL|$$|5mM|0.4995mL|2.4974mL|4.9948mL|$$|10mM|0.2497mL|1.2487mL|2.4974mL| |
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亚太因
¥2390 - 5940
