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- 详细信息
- 技术资料
- 保存条件：
Store at -20℃，2 years
- 保质期：
Store at -20℃，2 years
- 英文名：
Eicosapentaenoic Acid
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
10417-94-4
- 规格：
100mg/50mg
| 规格： | 100mg | 产品价格： | ￥740.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥540.0 |
| 基本信息 | |
| CAS | No.10417-94-4 |
| 中文名称 | 二十碳五烯酸 |
| 英文名称 | Eicosapentaenoic Acid |
| 分子式 | C20H30O2 |
| 分子量 | 302.45 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥95% |
| 外观(性状) | Colorless to light yellow Liquid |
| 储存条件 | Store at -20℃，2 years |
| 密度 | 0.94g/mL |
| MDL | MFCD00065716 |
| SMILES | CC/C=CC/C=CC/C=CC/C=CC/C=CCCCC(=O)O |
| InChIKey | JAZBEHYOTPTENJ-JLNKQSITSA-N |
| InChI | InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4，6-7，9-10，12-13，15-16H，2，5，8，11，14，17-19H2，1H3，(H，21，22)/b4-3-，7-6-，10-9-，13-12-，16-15- |
| PubChem CID | 446284 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | Eicosapentaenoic Acid是一种ω-3脂肪酸,具有多种生物学活性。 |
| 生物活性 | Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation[1-3]. |
| In Vitro | Eicosapentaenoic Acid (100 μM; 1， 3， 24 h) causes a significant increase of H-Ras and N-Ras mRNA levels conditioning for 1 and 3 hours. K-Ras mRNA levels were not affected by Eicosapentaenoic Acid[1]. |
| 细胞实验 | Daily gavage of ω-3 PUFAs (300 mg docosahexaenoic acid [DHA] plus 60 mg eicosapentaenoic acid [EPA]) significantly attenuated the development of form deprivation myopia in guinea pigs and mice， as well as of lens-induced myopia in guinea pigs. Additionally， treatment with EPA antagonized hypoxia-induced myofibroblast transdifferentiation in cultured human scleral fibroblasts.[2] |
| 动物实验 | After one week of acclimatization with free access to standard mouse chow (commercial diet， 17.14% of energy from fat， 5.05 g/100 g) and water， the mice were randomly divided into nine groups each containing six mice and fed ALA series diets (1， 2.5， 5， or 7.5 wt%)， 5% ALA and EPA series diets (0.25， 0.5， 1 wt%)， EPA diet (2 wt%)， or the control diet (Ctl diet: depleted in ω-3 PUFA) for seven weeks.[3] |
| 数据来源文献 | [1]. Martins， J.G.， EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr， 2009. 28(5): p. 525-42 [2]. Miaozhen Pan， et al. Dietary ω-3 polyunsaturated fatty acids are protective for myopia. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104689118. [3]. Shun-he Wang， et al. Endogenous omega-3 long-chain fatty acid biosynthesis from alpha-linolenic acid is affected by substrate levels， gene expression， and product inhibition. RSC Adv.， 2017， 7， 40946-40951. |
| 单位 | 瓶 |
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IE1571 二十碳五烯酸 抑制剂/拮抗剂/激动剂 索莱宝
￥540 - 740
