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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Fipexide Hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
34161-23-4
- 规格：
25mg
| 基本信息 | |
| CAS | No.34161-23-4 |
| 中文名称 | 非哌西特盐酸盐 |
| 英文名称 | Fipexide Hydrochloride |
| 别名 | 盐酸非哌西特;盐酸苯醋椒哌嗪 |
| 分子式 | C20H22Cl2N2O4 |
| 分子量 | 425.31 |
| 溶解性 | Soluble in DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| SMILES | C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C(=O)COC4=CC=C(C=C4)Cl.Cl |
| InChIKey | MVOWQBJZZKOQNU-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H21ClN2O4.ClH/c21-16-2-4-17(5-3-16)25-13-20(24)23-9-7-22(8-10-23)12-15-1-6-18-19(11-15)27-14-26-18;/h1-6，11H，7-10，12-14H2;1H |
| PubChem CID | 161803 |
| 靶点 | Adenylate Cyclase |
| 通路 | GPCR & G Protein |
| 背景说明 | Fipexide 是对氯PAA衍生物，可以降低纹状体腺苷酸环化酶 (adenylate cyclase) 的活性，可用于老年痴呆的相关研究。 |
| 生物活性 | Fipexide hydrochloride， a parachloro-phenossiacetic acid derivative， is an orally active nootropic agent. Fipexide hydrochloride reduces striatal adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide hydrochloride is used for senile dementia research. Fipexide hydrochloride acts as a chemical inducer in callus formation， shoot regeneration and Agrobacterium infection[1][2]. |
| In Vitro | FPX was shown to act as a chemical inducer in callus formation， shoot regeneration and Agrobacterium infection. With regards to morphology， the cellular organization of FPX - induced calli differed from those produced under auxin/cytokinin conditions.Microarray analysis revealed that the expression of approximately 971 genes was up - regulated 2 - fold after a 2 d FPX treatment compared with non - treated plants. Among these 971 genes， 598 genes were also induced by auxin/cytokinin， whereas 373 genes were specifically expressed upon FPX treatment only.FPX can promote callus formations in rice， poplar， soybean， tomato and cucumber， and thus can be considered a useful tool for revealing the mechanisms of plant development and for use in plant transformation technologies.[2] |
| 细胞实验 | Deficit in active and inhibitory avoidance behaviour has been observed in pentylenetetrazole (PTZ)-kindled rats. This supports the view that memory deficit is an integral part of epilepsy.In the present study we examined the effect of the nootropic drugs piracetam and fipexide on memory deficit induced by PTZ - kindling in shuttle - box - and step - down - trained rats. The retention in piracetam - and fipexide - treated animals was significantly improved compared to the kindled controls.The favourable effect of nootropic drugs in cases of amnesia provoked by PTZ - kindling might be of interest in clinical practice.[3].Animal Model: Kindled rats[3];Dosage:10 mg/kg；Administration:Orally; 5-10 days；Result:Completely abolishes the memory deficit produced by kindling.Antagonized the amnestic effect of Pentylenetetrazole (PTZ) -kindling. |
| 数据来源文献 | [1]. A Marino， et al. Fipexide improvement of cognitive functions in rat: behavioural and neurochemical studies. Pharmacol Res. Mar-Apr 1990;22(2):179-87. [2]. Takeshi Nakano， et al.FPX is a Novel Chemical Inducer that Promotes Callus Formation and Shoot Regeneration in Plants. Plant Cell Physiol. 2018 Aug 1;59(8):1555-1567. [3]. M G Genkova-Papazova， et al. Piracetam and fipexide prevent PTZ-kindling-provoked amnesia in rats. Eur Neuropsychopharmacol. 1996 Nov;6(4):285-90. |
| 单位 | 瓶 |
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IF1430 非哌西特盐酸盐 抑制剂/拮抗剂/激动剂 索莱宝
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