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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Betaxolol Hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
63659-19-8
- 规格：
100mg/5mg/50mg/10mg
| 规格： | 100mg | 产品价格： | ￥1560.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥315.0 |
| 规格： | 50mg | 产品价格： | ￥920.0 |
| 规格： | 10mg | 产品价格： | ￥510.0 |
| 基本信息 | |
| CAS | No.63659-19-8 |
| 中文名称 | 盐酸倍他洛尔 |
| 英文名称 | Betaxolol Hydrochloride |
| 别名 | SL 75212 HCl |
| 分子式 | C18H30ClNO3 |
| 分子量 | 343.89 |
| 溶解性 | Soluble in Water/DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 264-384-3 |
| MDL | MFCD00242959 |
| SMILES | CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O.Cl |
| InChIKey | CHDPSNLJFOQTRK-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8，14，16-17，19-20H，3-4，9-13H2，1-2H3;1H |
| PubChem CID | 107952 |
| 靶点 | Adrenergic Receptor |
| 通路 | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| 背景说明 | 是一种 β1 ADr受体 (beta1 adrenergic receptor) 阻断剂，可用于高血压和青光眼的研究。 |
| 生物活性 | Betaxolol Hydrochloride 是一种β1ADr受体阻断剂，IC50是6 Μm，可用于高血压和青光眼的研究。[1-3] |
| IC50 | β1-adrenergic receptor: 6μM(IC50)[1] |
| In Vitro | The selective beta 2-antagonist ICI 118-551 caused a greater inhibition(IC50 approximately 7 x 10(-7))than the selective beta 1-antagonist betaxolol(IC50 approximately 6 x 10(-6)).[1] |
| 细胞实验 | SD rats treated with betaxolol(5 mg/kg via i.p. injection)during cocaine withdrawal exhibited a significant attenuation of anxiety-like behavior characterized by increased time spent in the open arms and increased entries into the open arms compared to animals treated with only saline during cocaine withdrawal.[2] A mean reduction in intraocular pressure of 15-35% occurs with both betaxolol and levobunolol and is reported to be maintained with prolonged use. Betaxolol is associated with a higher(25%)incidence of local ocular adverse reactions than timolol.[3] |
| 动物实验 | Male Sprague Dawley rats were administered intraperitoneal(i.p.)injections of cocaine(20 mg/kg)once daily for 14 days. Betaxolol(5 mg/kg via i.p. injection)was administered at 24 and then 44 h following the final chronic cocaine administration. Anxiety-like behavior was evaluated using the elevated plus maze test approximately 2 h following the last betaxolol injection.[1] |
| 数据来源文献 | [1]. Tang LQ，et al. Effect of beta-adrenergic agents on intracellular potential of rabbit ciliary epithelium. Curr Eye Res. 1998 Jan;17(1):24-30. [2]. Rudoy CA，et al. Betaxolol，a selective beta(1)-adrenergic receptor antagonist，diminishes anxiety-like behavior during early withdrawal from chronic cocaine administration in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1119-29. [3]. Lesar TS. Comparison of ophthalmic beta-blocking agents. Clin Pharm. 1987 Jun;6(6):451-63. |
| 单位 | 瓶 |
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文献和实验bSuKm1foWOq5wNpboNQLmlo2Fn6wS/ZjqQvb2Gy88CULhuQ5TVEaoQ2gtdU9TtPRtFgh/BbLYDrlNQtO4GHJJVoXvFg0UhwMJHFBz8InEEZPh1ZysOf82LTuunw2ReE8zcuwcvBs9FhSwx9ygL9MIXF3cE5dCHQW6tUCFBRmfdHz/iB3LBwEAHsR9N0y8571/wU9NGdk3x4RpaZL/f4OLeO2i7bi76ls+Z7gQPsYry5csjR44c9GX7BuIIRl9f
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检查时发现。 （二）肾癌的副瘤综合征： 30%的肾癌病人有因肿瘤引起的非特异性的全身症状，如肿瘤代谢产物引起的发热、乏力、消瘦、体重下降、恶液质、肝功异常、血沉快等。肾癌可引起自身免疫性疾病，如神经肌肉病变、淀粉样变等；亦可因肿瘤分泌特征性的内分泌激素如促红细胞生成素、甲状旁腺素、肠或胰高血糖素、肾素、前列腺素A、促性腺激素引起的异常表现，相应的临床表现为：红细胞增多症、高钙血症、高血糖、高血压、低血压、Cushing综合症等。 四、诊断 (一) 肾癌的临床诊断主要
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