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- 详细信息
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Azetidine-2-carboxylic Acid
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
2517-04-6
- 规格：
1g/500mg/100mg/250mg
| 规格： | 1g | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 500mg | 产品价格： | ￥450.0 |
| 规格： | 100mg | 产品价格： | ￥380.0 |
| 规格： | 250mg | 产品价格： | ￥410.0 |
| 基本信息 | |
| CAS | No.2517-04-6 |
| 中文名称 | L-铃兰氨酸 |
| 英文名称 | Azetidine-2-carboxylic Acid |
| 别名 | ;2-氮杂环丁烷甲酸;氮杂环丁烷-2-羧酸;2-Azetidinecarboxylicacid;2-azetidine-carboxylicacid;丁二酸-N，N-二甲基酰肼;N-二MMA基琥珀酰胺; |
| 分子式 | C4H7NO2 |
| 分子量 | 101.1 |
| 溶解性 | Soluble in Water |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 219-740-2 |
| MDL | MFCD00066660 |
| SMILES | C1CNC1C(=O)O |
| InChIKey | IADUEWIQBXOCDZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C4H7NO2/c6-4(7)3-1-2-5-3/h3,5H,1-2H2,(H,6,7) |
| PubChem CID | 17288 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 是 S-allyl-l-cysteine 的立体异构体,存在于大蒜中,具有免疫调节作用。 |
| 生物活性 | Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent[1][2]. |
| In Vitro | Administration of azetidine-2-carboxylic acid to growing chick embryos for 5 days produced a marked arrest in the accumulation of collagen and a significant in_x0002_crease in the fragility of the embryos.The effect on collagen in embryos treated with 375 or 500 ~g per day was specific since the decrease in collagen accumulation was consistently over twice the effect on non-collagen proteins. The experiments with cartilage in vitro demonstrated that the principal effect of azetidine-2-carboxylic acid in the first 2 h or so is to increase the intracellular pool of collagen because the collagen containing the analogue cannot be extruded at a normal rate.[3] |
| 细胞实验 | Autoradiographs from the embryos labeled in vivo indicated that cells treated with azetidine-2-carboxylic acid for 5 days do not adapt to the repeated exposure to the analogue and they still do not extrude collagen containing the analogue at a normal rate. [3] |
| 动物实验 | Azetidine-2-carboxylic acid was dissolved in distilled water and 0.2 ml of solution in the appropriate concentration was applied to the air sack of the chick erabryos daily from day 8 to day 12. Control embryos received 0.2 ml of distilled water daily. [14C] Proline or ~3，4-3H21proline was administered by adding the labeled amino acid to the solution of azetidine-2-carboxylic acid or distilled water which was ad_x0002_ministered to the chick embryos 4-48 h prior to the time the embryos were killed. Femurs and tibiae were removed from the embryo by microscopic dissection.[3] |
| 数据来源文献 | [1]. Rubenstein E， et al. Azetidine-2-carboxylic acid in the food chain. Phytochemistry. 2009 Jan;70(1):100-4. [2]. Rubenstein E， et al. Misincorporation of the proline analog azetidine-2-carboxylic acid in the pathogenesis of multiple sclerosis: a hypothesis. J Neuropathol Exp Neurol. 2008 Nov;67(11):1035-40. [3]. Lane JM， et al. Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos. Biochim Biophys Acta. 1971 Jun 29;236(3):517-27. |
| 单位 | 瓶 |
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IA3740 L-铃兰氨酸 抑制剂/拮抗剂/激动剂 索莱宝
￥380 - 500
