2-hydroxy Atorvastatin (calciu

阿托伐他汀的活性代谢物；由阿托伐他汀通过CYP3A4形成；以浓度依赖性方式分别抑制DLPC囊泡和人类LDL中的脂质氢过氧化物形成和硫酸铜诱导的TBARS形成；减少原代大鼠皮质神经元中OGD诱导的细胞死亡，并在OGD后600nM处增加GABA能神经元中CREB的磷酸化。An active metabolite of atorvastatin; formed from atorvastatin by CYP3A4; inhibits lipid hydroperoxide formation and copper sulfate-induced TBARS formation in DLPC vesicles and human LDL, respectively, in a concentration-dependent manner; reduces OGD-induced cell death in primary rat cortical neurons and increases phosphorylation of CREB in GABAergic neurons at 600 nM following OGD.分子式C33H34FN2O6 • 1/2Ca分子量593.7O=C(C1=C(C(C)C)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C2=CC=C(F)C=C2)=C1C3=CC=CC=C3)NC4=CC=CC=C4O.O=C(C5=C(C(C)C)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C6=CC=C(F)C=C6)=C5C7=CC=CC=C7)NC8=CC=CC=C8O.[Ca+2]