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文献和实验Radiometal Labeling of Antibodies and Antibody Fragments for Imaging and Therapy
Monoclonal antibodies (MAbs) are highly selective agents for delivering radiation to tumors both for in vivo imaging (radioimmunoscintigraphy, RIS) and for therapy (radioimmunotherapy, RIT). Antibody-based radiopharmaceuticals can be labeled
Competing Chromosomal Proteins from Drosophila Polytene Chromosomes Using Modified Histone Peptides
of binding". For this reason it is essential to include an internal control antibody for chromosome morphology and antibody access. For this internal control I use a mouse monoclonal anti-Modulo antibody (Perrin et al ., 1998; the antibody was obtained
," made up of fragments of up to seven nucleosomes in length, is incubated with an antiserum directed against the histone modification of interest. The antibody-bound fraction is separated from the unbound fraction and, after extraction of genomic DNA from the bound
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