IgG Fc (mouse) Monoclonal Anti

【翻译】Development trends for monoclonal antibody cancer therapeutics

). However, since 2000, humanized and human mAbs have been entering clinical study at approximately the same rate (4.3 versus 4.5 mAbs per year, respectively). Figure 1 | Categories of monoclonal antibody cancer therapeutics entering clinical study during 1980–1989

Rapid Isotyping of Mouse Monoclonal Antibodies

, isotyping is useful to control lot to lot consistency, detect contamination by another antibody, and identify hybridoma switch variants (see Notes 2 –8 for further comment on applications). Table 1  Isotype-Dependent Properties of Monoclonal

Generation of Antibody Molecules Through Antibody Engineering

been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional