Gap 19 (trifluoroacetate salt)

一种Cx43半通道抑制剂；在表达Cx43的HeLa细胞中抑制膜电位（Qm），IC50值约为6.5µM，同时在100µM浓度下抑制分离的豚鼠心肌细胞中的Cx43半通道电流。An inhibitor of Cx43 hemichannels; suppresses Qm in HeLa cells expressing Cx43 (IC50 = ~6.5 µM), as well as Cx43 hemichannel currents in isolated guinea pig cardiomyocytes at 100 µM; inhibits glutamate-induced ATP release in primary mouse astrocytes; decreases cortical neuronal loss, infarct volume, and the number of errors in a foot fault test in a mouse model of MCAO-induced cerebral ischemia and reperfusion injury at 300 µg/kg, i.c.v.; reduces infarct size in a mouse model of LAD ligation-induced myocardial ischemia and reperfusion injury at 25 mg/kg.分子式C55H96N14O13 • XCF3COOH分子量1161.4NCCCC[C@H](N)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O