Tat-Gap 19 (trifluoroacetate s

Cx43半通道的肽抑制剂；浓度为10µM时可抑制大鼠原代肝细胞中谷氨酸诱导的ATP释放；浓度为25mg/kg时可减少小鼠MCAO诱发的脑缺血再灌注损伤模型中的梗塞体积；以每天1mg/kg腹腔注射剂量输注时可减少硫代乙酰胺诱发的肝损伤小鼠模型中的纤维化病变面积和表达α-SMA的肝星状细胞面积；可增加从同一只小鼠中分离的肝细胞中的SOD活性。A peptide inhibitor of Cx43 hemichannels; inhibits glutamate-induced ATP release in primary rat hepatocytes at 10 µM; reduces infarct volume in a mouse model of cerebral ischemia-reperfusion injury induced by MCAO at 25 mg/kg; reduces fibrotic lesion area and the area of hepatic stellate cells expressing α-SMA in a mouse model of thioacetamide-induced liver injury when infused at 1 mg/kg per day, i.p.; increases SOD activity in hepatic cells isolated from the same mice.分子式C119H212N46O26 • XCF3COOH分子量2703.3OC(C(F)(F)F)=O.O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(N)=O)C(N[C@@](C(N[C@@H](CCC(O)=O)C(N[C@@](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@@H](CCCCN[H])C(O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(O)C=C2)N[H]