QN523

一种抗癌剂；对MiaPaCa-2、PANC-1和BxPC-3胰腺癌细胞具有细胞毒性（IC50s分别为0.11、0.5和3.3µM）；在0.5µM浓度下诱导MiaPaCa-2细胞在S期细胞周期停滞；增加MiaPaCa-2细胞中的GRP78、DDIT3、ATF3、GDF15、WIPI1、GABARAPL1和LC3-II水平；减少MiaPaCa-2小鼠异种移植模型中的肿瘤体积。An anticancer agent; cytotoxic to MiaPaCa-2, PANC-1, and BxPC-3 pancreatic cancer cells (IC50s = 0.11, 0.5, and 3.3 µM, respectively); induces cell cycle arrest at the S phase in MiaPaCa-2 cells at 0.5 µM; increases levels of GRP78, DDIT3, ATF3, GDF15, WIPI1, GABARAPL1, and LC3-II in MiaPaCa-2 cells; reduces tumor volume in a MiaPaCa-2 mouse xenograft model.分子式C14H10N4O分子量250.3O=C(C1=NC=CN=C1)NC2=CC=CC3=C2N=CC=C3