RAMB4

泛素-蛋白酶体系统抑制剂；在10µM无细胞测定中，可增加HeLa细胞中多泛素化蛋白质的水平，但不抑制20S蛋白酶体的糜蛋白酶样、胰蛋白酶样或肽谷氨酰肽水解样活性；降低HeLa细胞的活力（IC50=2µM）。An inhibitor of the ubiquitin-proteasome system; increases the levels of polyubiquitinated proteins in HeLa cells, but does not inhibit the chymotrypsin-like, trypsin-like, or peptidylglutamyl peptide hydrolyzing-like activities of the 20S proteasome, in cell-free assays at 10 µM; decreases the viability of HeLa cells (IC50 = 2 µM).分子式C19H13Cl4NO分子量413.1O=C1C(CNCC1=CC2=CC=C(C(Cl)=C2)Cl)=CC3=CC=C(C(Cl)=C3)Cl