Arnicolide D

具有抗癌活性的倍半萜内酯；抑制MDA-MB-231、MDA-MB-468和MCF-7人乳腺癌细胞的增殖（48小时后IC50s分别为5.211、3.405和9.083µM）；在2.5、5和10µM时抑制MDA-MB-231细胞的迁移；在25和50mg/kg时减小MDA-MB-231原位小鼠异种移植模型中的肿瘤体积。A sesquiterpene lactone with anticancer activity; inhibits the proliferation of MDA-MB-231, MDA-MB-468, and MCF-7 human breast cancer cells (IC50s = 5.211, 3.405, and 9.083 µM, respectively, after 48 hours); inhibits migration of MDA-MB-231 cells at 2.5, 5, and 10 µM; reduces tumor volume in an MDA-MB-231 orthotopic mouse xenograft model at 25 and 50 mg/kg .分子式C19H24O5分子量332.4CC(C(O[C@H]1[C@@]2([H])[C@@](OC([C@H]2C)=O)([H])C[C@H]([C@@]3([H])[C@]1(C(C=C3)=O)C)C)=O)=C