Continentalic Acid

一种具有多种生物活性的二萜酸；对MSSA和MRSA临床分离株有效（MIC分别为8和8-16µg/ml）；在200µM浓度下诱导U-2932、OCI-LY1和Ramos(RA1)B细胞淋巴瘤细胞凋亡；在大肠杆菌和LPS诱发的肾损伤小鼠模型中改善肾功能并降低肾脏MDA和过氧化物酶水平、NO生成和中性粒细胞浸润。A diterpenic acid with diverse biological activities; active against MSSA and clinical isolates of MRSA (MICs = 8 and 8-16 µg/ml, respectively); induces apoptosis in U-2932, OCI-LY1, and Ramos (RA 1) B cell lymphoma cells at 200 µM; improves renal function and decreases renal MDA and peroxidase levels, NO production, and neutrophil infiltration in a mouse model of E. coli- and LPS-induced renal injury.分子式C20H30O2分子量302.5C[C@]12[C@@](CCC3=C[C@](C=C)(C)CC[C@]32[H])([H])[C@@](C)(CCC1)C(O)=O