Adenosine amine congener

腺苷A1受体激动剂；选择性地结合腺苷A1而非A2A和A3受体（对于大鼠受体，Kis分别为0.85、210和281nM）；在双侧颈动脉闭塞诱发的脑缺血的沙鼠模型中，以75µg/kg的剂量增加海马CA1区的存活率并防止神经元损伤；在100µg/kg的剂量下，在暴露于110dB噪音后，可防止大鼠的听觉阈值变化以及内外毛细胞损失。An adenosine A1 receptor agonist; selectively binds adenosine A1 over A2A and A3 receptors (Kis = 0.85, 210, and 281 nM, respectively, for the rat receptors); increases survival and prevents neuronal damage in the hippocampal CA1 region in a gerbil model of bilateral carotid artery occlusion-induced cerebral ischemia at 75 µg/kg; protects against auditory threshold shifits and inner and outer hair cell loss in rats following noise exposure at 110 dB at 100 µg/kg.分子式C28H32N8O6分子量576.6O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC(NC4=CC=C(C=C4)CC(NC5=CC=C(C=C5)CC(NCCN)=O)=O)=C3N=C2