WRW4 (trifluoroacetate salt)

FPR2（IC50=0.23µM）和FPR3的肽拮抗剂；在10µM浓度下，抑制表达FPR2的RBL-2H3细胞和分离的人单核细胞中F2L诱导的WKYMVm的细胞内钙和趋化性的增加；在10µM浓度下，预防分离的人中性粒细胞中Aβ42诱导的超氧化物产生；在由肺炎链球菌诱发的急性肺损伤的小鼠模型中，在有和无头孢曲松存在的情况下，增加肺水肿和BALF蛋白水平，浓度为1mg/kg。A peptide antagonist of FPR2 (IC50 = 0.23 µM) and FPR3; inhibits increases in intracellular calcium and chemotaxis induced WKYMVm in RBL-2H3 cells expressing FPR2 and by F2L in isolated human monocytes at 10 µM; prevents Aβ42-induced production of superoxide in isolated human neutrophils at 10 µM; increases lung edema and BALF protein levels in the absence and presence ceftriaxone in a mouse model of acute lung injury induced by S. pneumoniae at 1 mg/kg.分子式C61H65N15O6 • XCF3COOH分子量1104.3O=C([C@H](CCCNC(N)=N)NC([C@@H](N)CC1=CNC2=CC=CC=C21)=O)N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(N[C@@H](CC7=CNC8=C7C=CC=C8)C(N[C@@H](CC9=CNC%10=C9C=CC=C%10)C(N)=O)=O)=O)=O.OC(C(F)(F)F)=O