Stercobilin (hydrochloride)

粪便色素和胆红素代谢物；在0.5-17µM浓度下，在HepG2细胞的彗星试验中诱导DNA损伤；在20和30µM浓度下，在报告试验中诱导NF-κB激活，并增加RAW 264.7巨噬细胞中编码TNF-α、IL-1β、IL-6、iNOS和COX-2的基因表达；ob/ob小鼠的粪便和血浆水平升高。A fecal pigment and metabolite of bilirubin; induces DNA damage in a comet assay in HepG2 cells at 0.5-17 µM; induces activation of NF-κB in a reporter assay and increases the expression of the genes encoding TNF-α, IL-1β, IL-6, iNOS, and COX-2 in RAW 264.7 macrophages at 20 and 30 µM; fecal and plasma levels are increased in ob/ob mice.分子式C33H46N4O6 • XHCl分子量594.8OC(CCC1=C(C)C(C[C@@H]2NC([C@H](CC)[C@H]2C)=O)=N/C1=C\C3=C(CCC(O)=O)C(C)=C(C[C@@H]4NC([C@H](C)[C@H]4CC)=O)N3)=O.Cl