2-hydroxy Oleic Acid

一种合成的单不饱和羟基脂肪酸；在PE:2-羟基油酸摩尔比为20:1时，可使牛肝PE膜的层状到六边形转变温度降低约12.5°C；增加A549细胞中的PKCα水平并降低其增殖；在75和200mg/kg剂量下降低A549小鼠异种移植模型中的肿瘤生长；已用于脂质体的生成。A synthetic monounsaturated hydroxylated fatty acid; decreases the lamellar-to-hexagonal transition temperature of bovine liver PE membranes by ~12.5°C at a 20:1 molar ratio of PE:2-hydroxy oleic acid; increases levels of PKCα in and decreases proliferation of A549 cells; reduces tumor growth in an A549 mouse xenograft model at 75 and 200 mg/kg; has been used in the generation of liposomes.分子式C18H34O3分子量298.5CCCCCCCC/C=C\CCCCCCC(O)C(O)=O