Eriodictyol 7-O-glucoside

一种黄烷酮葡萄糖苷；在无细胞测定中清除羟基和超氧化物阴离子自由基（IC50分别为0.28和0.3mM）；在报告基因测定中激活Nrf2；在80µM浓度下保护HRMC免受顺铂诱导的细胞毒性，但对A549或MDA-MB-231细胞无效；在30mg/kg浓度下减轻MCAO诱发的脑缺血大鼠模型中的神经功能缺损并减少梗塞体积。A flavanone glucoside; scavenges hydroxyl and superoxide anion radicals in cell-free assays (IC50s = 0.28 and 0.3 mM, respectively); activates Nrf2 in a reporter assay; protects against cisplatin-induced cytotoxicity in HRMCs, but not A549 or MDA-MB-231 cells, at 80 µM; attenuates neurological deficits and reduces infarct volume in a rat model of MCAO-induced cerebral ischemia at 30 mg/kg.分子式C21H22O11分子量450.4OC1=C2C(O[C@@H](CC2=O)C3=CC(O)=C(O)C=C3)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1