Valproic Acid

戊酸类似物；抑制I类HDAC（IC50=~2mM）；减少从新生大鼠背根神经节分离的感觉神经元的轴突分支数量；抑制淀粉样蛋白β沉积和神经斑块形成，并减少阿尔茨海默病APP23转基因小鼠模型的Morris水迷宫测试中的逃逸潜伏期；在小鼠戊四唑癫痫发作阈值测试中具有抗惊厥活性（ED50=0.71mmol/kg）；在≥1.2mmol/kg时诱导神经毒性。An analog of valeric acid; inhibits class I HDACs (IC50s = ~2 mM); decreases the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia; inhibits amyloid-β deposition and neuritic plaque formation and decreases escape latency in the Morris water maze test in the APP23 transgenic mouse model of Alzheimer's disease; has anticonvulsant activity in the pentylenetetrazole seizure threshold test in mice (ED50 = 0.71 mmol/kg); induces neurotoxicity at ≥1.2 mmol/kg.分子式C8H16O2分子量144.2CCCC(CCC)C(O)=O