Galgravin

一种具有多种生物活性的木酚素；在分离的兔血小板膜上抑制血小板活化因子（PAF）的结合（IC50=4.5µM）；在小鼠骨髓来源的巨噬细胞中，抑制RANKL和M-CSF诱导的破骨细胞形成（浓度范围为3-100µM）；在原代大鼠海马神经元中，保护细胞免受人Aβ（25-35）诱导的细胞毒性（10µM）；在小鼠中，以20mg/kg的剂量减少乙酸诱导的腹部收缩，在大鼠中减少角叉菜胶诱导的足趾水肿。A lignan with diverse biological activities; inhibits the binding of PAF to isolated rabbit platelet plasma membranes (IC50 = 4.5 µM); inhibits RANKL- and M-CSF-induced osteoclast formation in mouse bone marrow-derived macrophages at 3-100 µM; protects against cytotoxicity induced by human Aβ (25-35) in primary rat hippocampal neurons at 10 µM; reduces acetic acid-induced abdominal constrictions in mice and carrageenan-induced paw edema in rats at 20 mg/kg.分子式C22H28O5分子量372.5C[C@H]1[C@H](C2=CC(OC)=C(OC)C=C2)O[C@H](C3=CC(OC)=C(OC)C=C3)[C@H]1C