Hypaphorine

一种具有植物生长调节和抗炎活性的吲哚生物碱；可逆转吲哚-3-乙酸诱导的E.globulus幼苗根部生长抑制；抑制12.5-50µM的LPS诱导BEAS-2B细胞凋亡；在10mg/kg剂量下，可降低LPS诱导的急性肺损伤大鼠模型的肺损伤严重程度和BALF中性粒细胞浸润。An indole alkaloid with plant growth regulatory and anti-inflammatory activities; reverses indole-3-acetic acid-induced inhibition of E. globulus seedling root growth; inhibits LPS-induced apoptosis in BEAS-2B cells from 12.5-50 µM; decreases the severity of lung injury and BALF neutrophil infiltration in a rat model of LPS-induced acute lung injury at 10 mg/kg.分子式C14H18N2O2分子量246.3C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC2=CC=CC=C12