Dictamnine

一种具有多种生物活性的生物碱；浓度为100µg/ml时，可抑制清洗过的分离兔血小板中花生四烯酸、胶原蛋白、凝血酶或PAF诱导的血小板聚集；对人类KB口腔癌细胞、HeLa宫颈癌细胞和DLD-1结肠癌细胞具有细胞毒性（EC50s分别为20.55、2.5和6.4µg/ml），并在50-200µM浓度下诱导A549、PC-9和EBC-1人肺癌细胞凋亡；浓度为150或200mg/kg时，可增加小鼠血清ALT和ALP活性并诱导肝细胞坏死。An alkaloid with diverse biological activities; inhibits arachidonic acid-, collagen-, thrombin-, or PAF-induced platelet aggregation in washed isolated rabbit platelets at 100 µg/ml; cytotoxic to human KB oral, HeLa cervical, and DLD-1 colon cancer cells (EC50s = 20.55, 2.5, and 6.4 µg/ml, respectively) and induces apoptosis in A549, PC-9, and EBC-1 human lung cancer cells from 50-200 µM; increases serum ALT and ALP activities and induces hepatocyte necrosis in mice at 150 or 200 mg/kg.分子式C12H9NO2分子量199.2COC1=C2C=COC2=NC3=CC=CC=C13