Bruceantin

一种具有多种生物活性的类苦素；抑制HeLa细胞、网织红细胞和网织红细胞裂解物中的蛋白质合成（IC50分别为30、40和1,600nM）；对氯喹敏感和抗性的恶性疟原虫菌株有效（IC50分别为8和13nM）；诱导HL-60白血病和RPMI-8226多发性骨髓瘤细胞凋亡（IC50分别为12.2和12.8nM）；在RPMI-8226小鼠异种移植模型中以5mg/kg诱导肿瘤消退。A quassinoid with diverse biological activities; inhibits protein synthesis in HeLa cells, reticulocytes, and reticulocyte lysates (IC50s = 30, 40, and 1,600 nM, respectively); active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50s = 8 and 13 nM, respectively); induces apoptosis in HL-60 leukemia and RPMI-8226 multiple myeloma cells (IC50s = 12.2 and 12.8 nM, respectively); induces tumor regression in an RPMI-8226 mouse xenograft model at 5 mg/kg.分子式C28H36O11分子量548.6COC([C@]12[C@@]3([H])[C@@]4(CO2)[C@@]([C@H]([C@@H]1O)O)([H])[C@@]5([C@@](C(C)=C(C(C5)=O)O)([H])C[C@@]4([H])OC([C@@H]3OC(/C=C(C)/C(C)C)=O)=O)C)=O