Nuciferine

一种具有多种生物活性的生物碱；是多巴胺D2受体的部分激动剂，也是血清素受体亚型5-HT7的反向激动剂，也是5-HT2B和5-HT2C受体的拮抗剂（EC50s分别为65.07、150、478和131nM）；是血吸虫Sm.5-HTRL受体的拮抗剂（IC50=240nM）；在10µM时抑制5-HT诱导的曼氏血吸虫幼虫和成虫运动能力；激活PPARα、PPARβ/δ和PPARγ转录活性；在10、20和40µM时防止RSL3诱导的HK-2和HEK293T细胞中的铁凋亡；降低高脂饮食诱发的高脂血症小鼠模型中的血清高脂血症和肝脏脂肪变性。An alkaloid with diverse biological activities; partial agonist at dopamine D2 receptors, as well as an inverse agonist at the serotonin receptor subtype 5-HT7, and an antagonist at the 5-HT2B and 5-HT2C receptors (EC50s = 65.07, 150, 478, and 131 nM, respectively); an antagonist at schistosome Sm.5-HTRL receptors (IC50 = 240 nM); inhibits 5-HT-induced motility of larval and adult S. mansoni at 10 µM; activates PPARα, PPARβ/δ, and PPARγ transcriptional activity; prevents RSL3-induced ferroptotic cell death in HK-2 and HEK293T cells at 10, 20, and 40 µM; reduces serum hyperlipidemia and hepatic steatosis in a mouse model of high-fat diet-induced hyperlipidemia.分子式C19H21NO2分子量295.4COC1=C2C3=C(C=C1OC)CCN(C)[C@]3([H])CC4=CC=CC=C42