Aurothioglucose (hydrate)

TrxR抑制剂（人胎盘酶的IC50=0.065µM）；对谷胱甘肽还原酶和GPX的TrxR选择性（IC50s分别为>100和80µM）；在100µM时抑制分离的人类风湿滑膜成纤维细胞中IL-1β诱导的IL-6和IL-8的产生；在10和25µM时降低潜伏感染HIV-1的OM10.1细胞中TNF-α诱导的HIV-1复制；在25mg/kg时提高由LPS和高氧诱发的ARDS小鼠模型的存活率；在遗传性糖尿病KK小鼠中诱导肥胖并增加食物摄入量和血糖水平。A TrxR inhibitor (IC50 = 0.065 µM for the human placental enzyme); selective for TrxR over glutathione reductase and GPX (IC50s = >100 and 80 µM, respectively); inhibits IL-1β-induced production of IL-6 and IL-8 in isolated human rheumatoid synovial fibroblasts at 100 µM; reduces HIV-1 replication induced by TNF-α in OM10.1 cells latently infected with HIV-1 at 10 and 25 µM; improves survival in a mouse model of ARDS induced by LPS and hyperoxia at 25 mg/kg; induces obesity and increases food intake and blood glucose levels in genetically diabetic KK mice.分子式C6H11AuO5S • XH2O分子量392.2O[C@@H]([C@@H]1O)[C@]([OH][Au+][S-]2)([H])C2O[C@@H]1CO.O