Rosmanol

一种具有多种生物活性的多酚；α-葡萄糖苷酶和α淀粉酶的抑制剂（IC50分别为16.4和40.9µg/ml）；诱导COLO 205细胞凋亡(IC50=~42µM)；抑制LPS诱导的PGE2产生，并降低RAW 264.7巨噬细胞中LPS诱导的NF-κB、iNOS和COX-2活性（浓度为2.5和5µM）；在小鼠中分别以30-100mg/kg的浓度表现出镇痛、抗抑郁和抗焦虑作用。A polyphenol with diverse biological activities; an inhibitor of α-glucosidase and α amylase (IC50s = 16.4 and 40.9 µg/ml, respectively); induces apoptosis in COLO 205 cells (IC50 = ~42 µM); inhibits LPS-induced PGE2 production, as well as reduces LPS-induced NF-κB, iNOS, and COX-2 activity, in RAW 264.7 macrophages at 2.5 and 5 µM; has antinociceptive, antidepressant-like, and anxiolytic-like activity in mice at 30-100 mg/kg, respectively.分子式C20H26O5分子量346.4O=C1[C@@]23C4=C(O)C(O)=C(C(C)C)C=C4[C@@H]([C@@H](O1)[C@@]2([H])C(C)(CCC3)C)O