Columbamine

一种具有多种生物活性的生物碱；小檗碱的代谢物；抑制CYP3A4（IC50=30.6µM）；对恶性疟原虫有活性（IC50=1.92µM）；分别在3µM和15µM时降低HepG2细胞的葡萄糖消耗和甘油三酯水平；在56mg/kg时减轻小鼠二甲苯引起的耳部水肿和乙酸引起的翻滚。An alkaloid with diverse biological activities; a metabolite of berberine; inhibits CYP3A4 (IC50 = 30.6 µM); active against P. falciparum (IC50 = 1.92 µM); decreases glucose consumption of, and triglyceride levels in, HepG2 cells at 3 and 15 µM, respectively; reduces xylene-induced ear edema and acetic acid-induced writhing in mice at 56 mg/kg.分子式C20H20NO4分子量338.4OC1=C(OC)C=C2CC[N+]3=C(C=C4C=CC(OC)=C(C4=C3)OC)C2=C1