4F 4PP (oxalate)

5-HT2A受体拮抗剂(Ki=5.3nM)；对5-HT2A受体的选择性优于5-HT1C受体(Ki=620nM)；抑制表达人类5-HT2A受体的Xenopus卵母细胞中的5-HT诱导电流(IC50=5.15µM)；脊髓灌注可在100µM时减少SNL诱发的神经性疼痛大鼠模型中电刺激脊髓场电位的面积。A 5-HT2A receptor antagonist (Ki = 5.3 nM); selective for 5-HT2A receptors over 5-HT1C receptors (Ki = 620 nM); inhibits 5-HT-induced current in Xenopus oocytes expressing human 5-HT2A receptors (IC50 = 5.15 µM); spinal superfusion reduces the area of electrically stimulated spinal field potentials in a rat model of SNL-induced neuropathic pain at 100 µM.分子式C22H26FNO • C2H2O4分子量429.5O=C(C(O)=O)O.O=C(C1CCN(CC1)CCCCC2=CC=CC=C2)C3=CC=C(C=C3)F