Benzarone

苯溴马隆的活性代谢物；抑制表达人类酶的非洲爪蟾卵母细胞中的URAT1（IC50=2.8µM）；抑制EYA3的酪氨酸磷酸酶活性（IC50=17.5µM）；在7.5µM时降低HUVEC的增殖和迁移；解开分离的大鼠肝线粒体中的氧化磷酸化；诱导分离的大鼠肝细胞凋亡和坏死；在25µg/g时降低A-673尤文氏肉瘤小鼠异种移植模型中的肿瘤生长。An active metabolite of benzbromarone; inhibits URAT1 in Xenopus oocytes expressing the human enzyme (IC50 = 2.8 µM); inhibits the tyrosine phosphatase activity of EYA3 (IC50 = 17.5 µM); reduces the proliferation and migration of HUVECs at 7.5 µM; uncouples oxidative phosphorylation in isolated rat liver mitochondria; induces apoptosis and necrosis in isolated rat hepatocytes; reduces tumor growth in an A-673 Ewing sarcoma mouse xenograft model at 25 µg/g.分子式C17H14O3分子量266.3O=C(C1=C(CC)OC2=CC=CC=C12)C3=CC=C(C=C3)O