Parbendazole

微管组装抑制剂（EC50=3µM）；降低HeLa细胞活力（EC50=0.53µM）；在使用HEK293细胞的报告试验中诱导基因毒性应激；在15mg/kg剂量下可减少但不会消除自然获得性或实验性线虫感染山羊的蠕虫负担；在怀孕第三周以60mg/kg剂量给怀孕母羊施用时，对羔羊胚胎有致畸作用。An inhibitor of microtubule assembly (EC50 = 3 µM); reduces viability of HeLa cells (EC50 = 0.53 µM); induces genotoxic stress in a reporter assay using HEK293 cells; reduces, but does not eradicate, worm burden in goats with naturally acquired or experimental nematode infections at 15 mg/kg; teratogenic to lamb embryos when administered to pregnant ewes at 60 mg/kg during the third week of pregnancy.分子式C13H17N3O2分子量247.3O=C(NC1=NC2=CC(CCCC)=CC=C2N1)OC