Verbenalin

一种环烯醚萜苷；浓度为258µM时，可分别抑制37%和48%的COX-1和COX-2活性；浓度为129µM时，可抑制AGS胃癌细胞、SF-268CNS癌细胞、HCT116结肠癌细胞、NCI H460肺癌细胞和MCF-7乳腺癌细胞的增殖；可减轻小鼠角叉菜诱发的爪水肿和TPA诱发的耳水肿；可降低分离的脑线粒体中MDA水平的升高和ROS的产生，并减少MCAO诱发的缺血再灌注损伤大鼠模型中的梗塞体积和神经功能缺损。An iridoid glucoside; inhibits the activities of COX-1 and COX-2 by 37 and 48%, respectively, at 258 µM; inhibits proliferation of AGS gastric, SF-268 CNS, HCT116 colon, NCI H460 lung, and MCF-7 breast cancer cells at 129 µM; reduces carrageen-induced paw edema and TPA-induced ear dema in mice; reduces increases in MDA levels and ROS production in isolated brain mitochondria isolated from, as well as decreases infarct volume and neurological deficits in, a rat model of MCAO-induced ischemia-reperfusion injury.分子式C17H24O10分子量388.4COC(C1=CO[C@H]([C@@]2([H])[C@]1([H])C(C[C@@H]2C)=O)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O